Among the common complex diseases, hypertension has been particularly unlucky in the
recent surge of positive results from genome-wide association studies. We summarize the …

Over the last two decades candidate gene association studies and genome-wide linkage
scans have met with little success in characterizing risk variants for hypertension. Several …

This brief commentary is based on the debate that took part in May 2010 in New York. We
describe the initial difficulties experienced in early genome-wide association studies of …

Over the past few years, it has been asserted that genome-wide association studies would
open the door to identifying primary genetic mechanisms underlying a variety of common …

Contemporary genomic tools now allow the fast and reliable genotyping of hundreds of
thousands of variants and permit an unbiased interrogation of the common variability across …

Despite its significant genetic component, the study of hypertension by genome‐wide
association presents more challenges than other common complex diseases. Its high …

Hypertension is a major risk factor for global mortality. Recent genome‐wide association
studies (GWAS) have led to successful identification of many genetic loci influencing blood …

The current landscape of genome-wide linkage studies of hypertension is acquiring novel
facets in an attempt to more appropriately grasp the genomic architecture of hypertension …

Similar to a tsunami wave, a new surge of genome-wide association studies in common
complex diseases has succeeded in identifying the causative genetic risk factors of …

Hypertension continues to be a major risk factor for global mortality, and recent genome-
wide association studies (GWAS) have expanded in size, leading to the identification of …