Improving recognition of antimicrobial peptides and target selectivity through machine learning and genetic programming

D Veltri, U Kamath, A Shehu - IEEE/ACM transactions on …, 2015 - ieeexplore.ieee.org
Growing bacterial resistance to antibiotics is spurring research on utilizing naturally-
occurring antimicrobial peptides (AMPs) as templates for novel drug design. While …

Machine learning for antimicrobial peptide identification and design

F Wan, F Wong, JJ Collins… - Nature Reviews …, 2024 - nature.com
Artificial intelligence (AI) and machine learning (ML) models are being deployed in many
domains of society and have recently reached the field of drug discovery. Given the …

Deep learning improves antimicrobial peptide recognition

D Veltri, U Kamath, A Shehu - Bioinformatics, 2018 - academic.oup.com
Motivation Bacterial resistance to antibiotics is a growing concern. Antimicrobial peptides
(AMPs), natural components of innate immunity, are popular targets for developing new …

Artificial intelligence-driven antimicrobial peptide discovery

P Szymczak, E Szczurek - Current Opinion in Structural Biology, 2023 - Elsevier
Antimicrobial peptides (AMPs) emerge as promising agents against antimicrobial resistance,
providing an alternative to conventional antibiotics. Artificial intelligence (AI) revolutionized …

A generative approach toward precision antimicrobial peptide design

JB Ferrell, JM Remington, CM Van Oort, M Sharafi… - BioRxiv, 2020 - biorxiv.org
As the emergence of bacterial resistance is outpacing the development of new antibiotics,
we must find cost-effective and innovative approaches to discover new antibacterial …

Encodings and models for antimicrobial peptide classification for multi-resistant pathogens

S Spänig, D Heider - BioData Mining, 2019 - Springer
Antimicrobial peptides (AMPs) are part of the inherent immune system. In fact, they occur in
almost all organisms including, eg, plants, animals, and humans. Remarkably, they show …

ABP-Finder: a tool to identify antibacterial peptides and the Gram-staining type of targeted bacteria

YB Ruiz-Blanco, G Agüero-Chapin, S Romero-Molina… - Antibiotics, 2022 - mdpi.com
Multi-drug resistance in bacteria is a major health problem worldwide. To overcome this
issue, new approaches allowing for the identification and development of antibacterial …

Deep learning regression model for antimicrobial peptide design

J Witten, Z Witten - BioRxiv, 2019 - biorxiv.org
Antimicrobial peptides (AMPs) are naturally occurring or synthetic peptides that show
promise for treating antibiotic-resistant pathogens. Machine learning techniques are …

Engineering selectively targeting antimicrobial peptides

M Lei, A Jayaraman, JA Van Deventer… - Annual review of …, 2021 - annualreviews.org
The rise of antibiotic-resistant strains of bacterial pathogens has necessitated the
development of new therapeutics. Antimicrobial peptides (AMPs) are a class of compounds …

Antimicrobial peptides: an update on classifications and databases

A Bin Hafeez, X Jiang, PJ Bergen, Y Zhu - International journal of …, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …