[HTML][HTML] Pharmacologic agents targeting autophagy

H Vakifahmetoglu-Norberg, H Xia… - The Journal of clinical …, 2015 - Am Soc Clin Investig
Autophagy is an important intracellular catabolic mechanism critically involved in regulating
tissue homeostasis. The implication of autophagy in human diseases and the need to …

Therapeutic targeting of autophagy in disease: biology and pharmacology

Y Cheng, X Ren, WN Hait, JM Yang - Pharmacological reviews, 2013 - ASPET
Autophagy, a process of self-digestion of the cytoplasm and organelles through which
cellular components are recycled for reuse or energy production, is an evolutionarily …

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

L Galluzzi, JM Bravo-San Pedro, B Levine… - Nature reviews Drug …, 2017 - nature.com
Autophagy is central to the maintenance of organismal homeostasis in both physiological
and pathological situations. Accordingly, alterations in autophagy have been linked to …

[HTML][HTML] Autophagy: a druggable process that is deregulated in aging and human disease

G Kroemer - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
Autophagy (“self-eating”) constitutes one of the most spectacular yet subtly regulated
phenomena in cell biology. Similarly to cell division, differentiation, and death, autophagy is …

Autophagy: a druggable process

E Morel, M Mehrpour, J Botti, N Dupont… - Annual Review of …, 2017 - annualreviews.org
Macroautophagy (hereafter called autophagy) is a vacuolar, lysosomal pathway for
catabolism of intracellular material that is conserved among eukaryotic cells. Autophagy …

Chemical modulators of autophagy as biological probes and potential therapeutics

A Fleming, T Noda, T Yoshimori… - Nature chemical …, 2011 - nature.com
Autophagy is an evolutionarily conserved mechanism for protein degradation that is critical
for the maintenance of homeostasis in man. Autophagy has unexpected pleiotropic functions …

Targeting autophagy in disease: established and new strategies

M Kocak, S Ezazi Erdi, G Jorba, I Maestro, J Farrés… - Autophagy, 2022 - Taylor & Francis
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …

Potential therapeutic applications of autophagy

DC Rubinsztein, JE Gestwicki, LO Murphy… - Nature reviews Drug …, 2007 - nature.com
Autophagy is a dynamic process of subcellular degradation, which has recently sparked
great interest as it is now recognized to be involved in various developmental processes and …

[HTML][HTML] Chemical screening approaches enabling drug discovery of autophagy modulators for biomedical applications in human diseases

PK Panda, A Fahrner, S Vats, E Seranova… - Frontiers in cell and …, 2019 - frontiersin.org
Autophagy is an intracellular degradation pathway for malfunctioning aggregation-prone
proteins, damaged organelles, unwanted macromolecules and invading pathogens. This …

[HTML][HTML] Following autophagy step by step

TE Hansen, T Johansen - BMC biology, 2011 - Springer
Autophagy is an evolutionarily conserved lysosomal degradation route for soluble
components of the cytosol and organelles. There is great interest in identifying compounds …