Background: Cardiovascular diseases (CVD) remain the leading cause of death worldwide,
while a lack of clarity on underlying mechanisms has hindered development of novel …

Circulating proteins are vital in human health and disease and are frequently used as
biomarkers for clinical decision-making or as targets for pharmacological intervention. By …

Despite widespread use of drugs targeting traditional cardiovascular risk factors such as
lipids and blood pressure, a high burden of coronary heart disease (CHD) remains, hence …

Background Genome-wide association studies (GWASs) have identified more than 150
genetic loci that demonstrate robust association with coronary artery disease (CAD). In …

Background Ischemic heart disease is one of the leading causes of mortality worldwide, and
thus calls for development of more effective therapeutic strategies. This study aimed to …

Background: Myocardial infarction (MI) is a leading cause of global mortality. Finding
effective drugs to treat MI is an urgent concern for clinicians. Proteome-wide Mendelian …

Objective—Genome-wide association studies have identified multiple genetic variants
affecting the risk of coronary artery disease (CAD). However, individually these explain only …

Identifying genetic variants associated with circulating protein concentrations (pQTLs) and
integrating them with variants from genome-wide association studies (GWAS) may illuminate …

Objectives Global cardiometabolic disease prevalence has grown rapidly over the years,
making it the leading cause of death worldwide. Proteins are crucial components in …

Background Coronary artery disease (CAD) remains the leading cause of mortality
worldwide despite enormous efforts devoted to its prevention and treatment. While many …