Stroke disrupts the homeostatic balance within the brain and is associated with a significant
accumulation of necrotic cellular debris, fluid, and peripheral immune cells in the central …

The blood‐brain barrier (BBB) is a highly regulated interface that separates the peripheral
circulation and the brain. It plays a vital role in regulating the trafficking of solutes, fluid, and …

Ischemic stroke is still among the leading causes of mortality and morbidity worldwide.
Despite intensive advancements in medical sciences, the clinical options to treat ischemic …

Immune and inflammatory responses actively modulate the pathophysiological processes of
acute brain injuries such as stroke. Soon after the onset of stroke, signals such as brain …

Excessive immune activation within the lesion site can be observed after stroke onset. Such
neuroinflammation within the brain parenchyma represents the innate immune response, as …

The nervous and immune systems control whole-body homeostasis and respond to various
types of tissue injury, including stroke, in a coordinated manner. Cerebral ischaemia and …

Ischemic stroke is one of the leading health issues and the major cause of permanent
disability in adults worldwide. Energy depletion and hypoxia occurring after ischemic stroke …

Neurological disorders affect over one billion lives each year worldwide. With population
aging, this number is on the rise, making neurological disorders a major public health …

Local and systemic inflammation contribute significantly to stroke risk factors as well as
determining stroke impact and outcome. Previously being considered as an immuno …

Immunological mechanisms have come into the focus of current translational stroke
research, and the modulation of neuroinflammatory pathways has been identified as a …