Identification of circulating proteins associated with blood pressure using Mendelian randomization
Background: Hypertension is a common modifiable risk factor for cardiovascular disease
and mortality. Pathophysiological mechanisms leading to hypertension remain incompletely …
and mortality. Pathophysiological mechanisms leading to hypertension remain incompletely …
Unraveling new factors associated with hypertension: the Mendelian randomization approach
M Grau-Perez, J Redon - Journal of Hypertension, 2020 - journals.lww.com
Hypertension (HTN) is a frequent condition with multifactorial cause in which genetic, fetal
and environmental factors interact to result in the final phenotype of blood pressure (BP) …
and environmental factors interact to result in the final phenotype of blood pressure (BP) …
Estimating the population benefits of blood pressure lowering: a wide‐angled Mendelian randomization study in UK Biobank
Background The causal relevance of elevated blood pressure for several cardiovascular
diseases (CVDs) is uncertain, as is the population impact of blood pressure lowering. This …
diseases (CVDs) is uncertain, as is the population impact of blood pressure lowering. This …
Association of cardiovascular risk factors and lifestyle behaviors with hypertension: a mendelian randomization study
S van Oort, JWJ Beulens, AJ van Ballegooijen… - …, 2020 - Am Heart Assoc
Hypertension is a major risk factor for cardiovascular disease and mortality. To identify
targets for the prevention of hypertension and its associated disease burden, we used the 2 …
targets for the prevention of hypertension and its associated disease burden, we used the 2 …
Proteome-wide Mendelian randomization identifies candidate causal proteins for cardiovascular diseases
C Li, N De Jay, S Sharma, KA Catalano, ER Holzinger… - medRxiv, 2023 - medrxiv.org
Background: Cardiovascular diseases (CVD) remain the leading cause of death worldwide,
while a lack of clarity on underlying mechanisms has hindered development of novel …
while a lack of clarity on underlying mechanisms has hindered development of novel …
Blood pressure and risk of cardiovascular disease in UK biobank: a mendelian randomization study
This study aims to evaluate the causal association of blood pressure (BP) with
cardiovascular diseases (CVDs). Two-sample Mendelian randomization was performed …
cardiovascular diseases (CVDs). Two-sample Mendelian randomization was performed …
Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols
S Padmanabhan, O Melander, C Hastie… - Journal of …, 2008 - journals.lww.com
Among the common complex diseases, hypertension has been particularly unlucky in the
recent surge of positive results from genome-wide association studies. We summarize the …
recent surge of positive results from genome-wide association studies. We summarize the …
Relationship between blood pressure and incident cardiovascular disease: linear and nonlinear Mendelian randomization analyses
Observational studies exploring whether there is a nonlinear effect of blood pressure on
cardiovascular disease (CVD) risk are hindered by confounding. This limitation can be …
cardiovascular disease (CVD) risk are hindered by confounding. This limitation can be …
[HTML][HTML] Associations of Circulating Biomarkers with Disease Risks: A Two-Sample Mendelian Randomization Study
Circulating biomarkers play a pivotal role in personalized medicine, offering potential for
disease screening, prevention, and treatment. Despite established associations between …
disease screening, prevention, and treatment. Despite established associations between …
Unravelling the distinct effects of systolic and diastolic blood pressure using Mendelian randomisation
A true discrepancy between the effect of systolic blood pressure (SBP) and diastolic blood
pressure (DBP) on cardiovascular (CV) outcomes remains unclear. This study performed …
pressure (DBP) on cardiovascular (CV) outcomes remains unclear. This study performed …
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