Several recent studies have provided insights into the genetic regulation of blood pressure.
A new study extends these findings by coupling genome-wide association study data with …

Blood pressure and kidney function have a bidirectional relation. Hypertension has long
been considered as a risk factor for kidney function decline. However, whether intensive …

Despite increased expenditure, productivity of the pharmaceutical industry has decreased
and currently 90% of developed molecules entering phase II and phase III clinical trials fail …

Introduction Many observational studies imply elevated blood pressure (BP) as a leading
risk factor for incident myocardial infarction (MI), but whether this relationship is causal …

Epidemiological research has revealed a galaxy of biomarkers, such as genes, molecules or
traits, which are associated with increased risk of atherosclerotic cardiovascular diseases …

Integration of knowledge generated from genetic studies on intermediate biomarkers and
CHD can provide a reliable approach to help assess causal pathways in coronary heart …

Cardiovascular disease encompasses several diverse pathological states that place a
heavy burden on individual and population health. The aetiological basis of many …

The known genetic architecture of blood pressure now comprises> 30 genes, with rare
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse …

At the dawn of the new decade, it is judicious to reflect on the boom of knowledge about
polygenic risk for essential hypertension supplied by the wealth of genome-wide association …