Associations of Proteomics With Hypertension and Systolic Blood Pressure: KORA S4/F4/FF4 and KORA Age1/Age2 Cohort Studies
BACKGROUND: Hypertension, a complex condition, is primarily defined based on blood
pressure readings without involving its pathophysiological mechanisms. We aimed to …
pressure readings without involving its pathophysiological mechanisms. We aimed to …
The total and direct effects of systolic and diastolic blood pressure on cardiovascular disease and longevity using Mendelian randomisation
II Chan, MK Kwok, CM Schooling - Scientific Reports, 2021 - nature.com
Abstract The 2017 American College of Cardiology/American Heart Association (ACC/AHA)
blood pressure (BP) guidelines lowered the hypertension threshold to≥ 130/80 mmHg, but …
blood pressure (BP) guidelines lowered the hypertension threshold to≥ 130/80 mmHg, but …
Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressure
Hypertension is a leading cause of premature death affecting more than a billion individuals
worldwide. Here we report on the genetic determinants of blood pressure (BP) traits …
worldwide. Here we report on the genetic determinants of blood pressure (BP) traits …
Mendelian randomization of circulating proteome identifies actionable targets in heart failure
Background Heart failure (HF) is a prevalent cause of mortality and morbidity. The molecular
drivers of HF are still largely unknown. Results We aimed to identify circulating proteins …
drivers of HF are still largely unknown. Results We aimed to identify circulating proteins …
Dissecting the polygenic basis of primary hypertension: identification of key pathway-specific components
Introduction and Objectives Genome-wide association studies have identified a high number
of genetic loci associated with hypertension suggesting the presence of an underlying …
of genetic loci associated with hypertension suggesting the presence of an underlying …
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci
Meta-analyses of association results for blood pressure using exome-centric single-variant
and gene-based tests identified 31 new loci in a discovery stage among 146,562 …
and gene-based tests identified 31 new loci in a discovery stage among 146,562 …
Quantitative real-time analysis of differentially expressed genes in peripheral blood samples of hypertension patients
Hypertension (HTN) is considered one of the most important and well-established reasons
for cardiovascular abnormalities, strokes, and premature mortality globally. This study was …
for cardiovascular abnormalities, strokes, and premature mortality globally. This study was …
Harnessing confounding and genetic pleiotropy to identify causes of disease through proteomics and Mendelian randomisation–'MR Fish'
AN Warwick, AD Hingorani, AP Khawaja… - medRxiv, 2024 - medrxiv.org
We propose an extension of the Mendelian randomisation (MR) paradigm ('MR-Fish') in
which the confounded disease association of an index protein ('the bait') is harnessed to …
which the confounded disease association of an index protein ('the bait') is harnessed to …
Genome-wide association analyses on blood pressure using three different phenotype definitions
Hypertension is the most prevalent disease worldwide and is itself a risk factor for cerebral,
cardiac, and renal diseases. The inconsistency of candidate genes suggested by previous …
cardiac, and renal diseases. The inconsistency of candidate genes suggested by previous …
Transcriptome-wide analysis identifies novel associations with blood pressure
T Zeller, C Schurmann, K Schramm, C Müller… - …, 2017 - Am Heart Assoc
Hypertension represents a major cardiovascular risk factor. The pathophysiology of
increased blood pressure (BP) is not yet completely understood. Transcriptome profiling …
increased blood pressure (BP) is not yet completely understood. Transcriptome profiling …