Background: Recent clinical guidelines support intensive blood pressure treatment targets.
However, observational data suggest that excessive diastolic blood pressure (DBP) …

Background Genome-wide association studies (GWAS) identified multiple loci for blood
pressure (BP) and hypertension. Six genes–ATP2B1, CACNB2, CYP17A1, JAG1 …

Hypertension is a polygenic disease that affects over 1.2 billion adults aged 30–79
worldwide. It is a major risk factor for renal, cerebrovascular, and cardiovascular diseases …

Background: Elevated blood pressure (BP) was associated with higher risk of heart failure,
but the relationship between BP-lowering via antihypertensive drugs and diminution of heart …

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

This brief commentary is based on the debate that took part in May 2010 in New York. We
describe the initial difficulties experienced in early genome-wide association studies of …

Weintraub et al Translational Medicine and Big Data 1203 associations based on candidate
gene evaluations. One striking example was the discovery that many sarcomere gene …

Over the past few years, it has been asserted that genome-wide association studies would
open the door to identifying primary genetic mechanisms underlying a variety of common …

Background—Genome-wide association studies have recently identified> 400 loci that
harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies …

Importance Mendelian randomization (MR) is a statistical approach that has become
increasingly popular in the field of cardiovascular disease research. It offers a way to infer …