Background: Traditional cardiovascular risk factors and the underlying genetic risk of
elevated blood pressure (BP) determine an individual's composite risk of developing …

Observational studies have elucidated the associations between dietary factors and
hypertension. Nevertheless, the exploration of these relationships using Mendelian …

High blood pressure affects over 1 billion people worldwide and is responsible for 50% of all
cardio vascular deaths. Despite numerous candidate gene and linkage studies, no …

Rationale: Hypertension affects≈ 30% of adults in industrialized countries and is the major
risk factor for cardiovascular disease. Objective: We sought to study the genetic effect of …

Background Coronary artery disease (CAD) remains the leading cause of mortality
worldwide despite enormous efforts devoted to its prevention and treatment. While many …

Hypertension is the leading risk factor for premature death worldwide. The identification of
modifiable causes of hypertension remains an imperative task. We aimed to investigate …

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

BACKGROUND: Inter-individual variation in blood pressure (BP) arises in part from
sequence variants within enhancers modulating the expression of causal genes. We …

Project. 7, 8 Completed nearly a decade ago, the genome project was an incredible effort: It
sought to identify all of the≈ 22 000 protein-coding genes in human DNA and to determine …

Background: Genome-wide association studies (GWAS) have identified more than a
thousand loci for blood pressure (BP). Functional genes in these loci are cell-type specific …