Emerging role of selective autophagy in human diseases
K Mizumura, AMK Choi, SW Ryter - Frontiers in pharmacology, 2014 - frontiersin.org
Autophagy was originally described as a highly conserved system for the degradation of
cytosol through a lysosome-dependent pathway. In response to starvation, autophagy …
cytosol through a lysosome-dependent pathway. In response to starvation, autophagy …
The emerging roles of autophagy in human diseases
Y Lei, DJ Klionsky - Biomedicines, 2021 - mdpi.com
Autophagy, a process of cellular self-digestion, delivers intracellular components including
superfluous and dysfunctional proteins and organelles to the lysosome for degradation and …
superfluous and dysfunctional proteins and organelles to the lysosome for degradation and …
Autophagy modulation as a potential therapeutic target for diverse diseases
Autophagy is an essential, conserved lysosomal degradation pathway that controls the
quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It …
quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It …
Aberrant regulation of autophagy in mammalian diseases
W Xie, J Zhou - Biology letters, 2018 - royalsocietypublishing.org
Autophagy is a major cellular metabolic pathway that facilitates degradation of a subset of
long-lived proteins and cytoplasmic organelles in eukaryotic cells. This pathway plays a vital …
long-lived proteins and cytoplasmic organelles in eukaryotic cells. This pathway plays a vital …
Autophagy: a druggable process that is deregulated in aging and human disease
G Kroemer - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
Autophagy (“self-eating”) constitutes one of the most spectacular yet subtly regulated
phenomena in cell biology. Similarly to cell division, differentiation, and death, autophagy is …
phenomena in cell biology. Similarly to cell division, differentiation, and death, autophagy is …
Targeting autophagy in disease: established and new strategies
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
Therapeutic modulation of autophagy: which disease comes first?
MC Maiuri, G Kroemer - Cell Death & Differentiation, 2019 - nature.com
The relentless efforts of thousands of researchers have allowed deciphering the molecular
machinery that regulates and executes autophagy, thus identifying multiple molecular …
machinery that regulates and executes autophagy, thus identifying multiple molecular …
Autophagy and disease
A Thorburn - Journal of biological chemistry, 2018 - ASBMB
As outlined in the accompanying Minireviews, autophagy is a complicated and highly
regulated process that delivers cellular material to lysosomes for degrading, recycling, and …
regulated process that delivers cellular material to lysosomes for degrading, recycling, and …
Autophagy: a druggable process
E Morel, M Mehrpour, J Botti, N Dupont… - Annual Review of …, 2017 - annualreviews.org
Macroautophagy (hereafter called autophagy) is a vacuolar, lysosomal pathway for
catabolism of intracellular material that is conserved among eukaryotic cells. Autophagy …
catabolism of intracellular material that is conserved among eukaryotic cells. Autophagy …
Autophagy: Can it become a potential therapeutic target?
XH Bao, Y Naomoto, HF Hao… - International …, 2010 - spandidos-publications.com
Autophagy is a cellular lysosomal degradation pathway involved in proteins and organelles
recycling for promoting cell survival, development and homeostasis. It is a multistep process …
recycling for promoting cell survival, development and homeostasis. It is a multistep process …