Immune checkpoint inhibitors in HCC: Cellular, molecular and systemic data

U Harkus, M Wankell, P Palamuthusingam… - Seminars in Cancer …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related deaths in the
world, and for patients with advanced disease there are few therapeutic options available …

[HTML][HTML] Immune checkpoint inhibitors in hepatocellular cancer: current understanding on mechanisms of resistance and biomarkers of response to treatment

AE Onuma, H Zhang, H Huang, TM Williams… - Gene …, 2020 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy worldwide
and a leading cause of death worldwide. Its incidence continues to increase in the US due to …

[HTML][HTML] Mechanisms of primary and acquired resistance to immune checkpoint inhibitors in patients with hepatocellular carcinoma

S De Lorenzo, F Tovoli, F Trevisani - Cancers, 2022 - mdpi.com
Simple Summary Immune checkpoint inhibitors (ICIs) are now a cornerstone of systemic
treatment for hepatocellular carcinoma (HCC). However, their efficacy is blunted by …

Immune checkpoint inhibitor resistance in hepatocellular carcinoma

Z Wang, Y Wang, P Gao, J Ding - Cancer letters, 2023 - Elsevier
The application of immune checkpoint inhibitors (ICIs) has markedly enhanced the treatment
of hepatocellular carcinoma (HCC), and HCC patients who respond to ICIs have shown …

[HTML][HTML] Advances in Immunotherapy for Hepatocellular Carcinoma (HCC)

F Bicer, C Kure, AA Ozluk, BF El-Rayes, M Akce - Current Oncology, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related
deaths in the world. More than half of patients with HCC present with advanced stage, and …

Immune checkpoint inhibitors in the treatment of hepatocellular carcinoma

Z Akbulut, B Aru, F Aydın… - Frontiers in …, 2024 - frontiersin.org
Despite advances in cancer treatment, hepatocellular carcinoma (HCC), the most common
form of liver cancer, remains a major public health problem worldwide. The immune …

[HTML][HTML] Overcoming resistance to immune checkpoint inhibitors in hepatocellular carcinoma: challenges and opportunities

Q Xie, P Zhang, Y Wang, W Mei, C Zeng - Frontiers in Oncology, 2022 - frontiersin.org
Hepatocellular carcinoma is one of the leading causes of cancer mortality globally, and its
incidence is increasing. Immune checkpoint therapy has revolutionized the treatment of …

Targets for immunotherapy of liver cancer

TF Greten, B Sangro - Journal of hepatology, 2018 - Elsevier
Drug development in hepatocellular carcinoma (HCC) has been characterised by many
failures in the past. Despite good rationales and promising phase II data, many phase III …

[HTML][HTML] Immune checkpoint inhibitors in hepatocellular carcinoma: current progresses and challenges

HT Liu, MJ Jiang, ZJ Deng, L Li, JL Huang… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common malignant tumor in the world
and its incidence is increasing in many countries. In recent years, with the deepening …

[HTML][HTML] Immune checkpoint inhibitors as monotherapy or within a combinatorial strategy in advanced hepatocellular carcinoma

M Guardascione, G Toffoli - International Journal of Molecular Sciences, 2020 - mdpi.com
In advanced-stage hepatocellular carcinoma (HCC), systemic treatment represents the
standard therapy. Target therapy has marked a new era based on a greater knowledge of …