Autophagy and cancer therapy

Y Kondo, S Kondo - Autophagy, 2006 - Taylor & Francis
Autophagy is a dynamic process of protein degradation which is typically observed during
nutrient deprivation. Recently, interest in autophagy has been renewed among oncologists …

[HTML][HTML] Autophagy-related signaling pathways are involved in cancer

C Chen, H Gao, X Su - Experimental and Therapeutic …, 2021 - spandidos-publications.com
Autophagy is a self-digestion process in cells that can maintain energy homeostasis under
normal circumstances. However, misfolded proteins, damaged mitochondria and other …

The multifaceted role of autophagy in cancer and the microenvironment

H Folkerts, S Hilgendorf, E Vellenga… - Medicinal research …, 2019 - Wiley Online Library
Autophagy is a crucial recycling process that is increasingly being recognized as an
important factor in cancer initiation, cancer (stem) cell maintenance as well as the …

The role of autophagy in cancer

N Santana-Codina, JD Mancias… - Annual Review of …, 2017 - annualreviews.org
Autophagy is a highly conserved and regulated process that targets proteins and damaged
organelles for lysosomal degradation to maintain cell metabolism, genomic integrity, and …

Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer

K Dalby, I Tekedereli, G Lopez-Berestein, B Ozpolat - Autophagy, 2010 - Taylor & Francis
Autophagy is an evolutionarily conserved lysosomal pathway for degrading cytoplasmic
proteins, macromolecules, and organelles. While autophagy has become one of the most …

[HTML][HTML] Autophagy modulation: a prudent approach in cancer treatment?

E Bishop, TD Bradshaw - Cancer chemotherapy and pharmacology, 2018 - Springer
Autophagy is a tightly controlled process comprising lysosomal degradation and recycling of
cellular proteins and organelles. In cancer, its paradoxical dual role of cytoprotection and …

Autophagy and cancer therapy

P Maycotte, A Thorburn - Cancer biology & therapy, 2011 - Taylor & Francis
Although autophagy has been shown to have a clear role as a tumor suppressor
mechanism, its role in cancer treatment is still controversial. Because autophagy is a survival …

Autophagy inducers in cancer

M Russo, GL Russo - Biochemical pharmacology, 2018 - Elsevier
Autophagy is a complex, physiological process devoted to degrade and recycle cellular
components. Proteins and organelles are first phagocytized by autophagosomes, then …

[HTML][HTML] The paradox of autophagy and its implication in cancer etiology and therapy

A Eisenberg-Lerner, A Kimchi - Apoptosis, 2009 - Springer
Autophagy is a cellular self-catabolic process in which cytoplasmic constituents are
sequestered in double membrane vesicles that fuse with lysosomes where they are …

Targeting autophagy in cancer

JMM Levy, CG Towers, A Thorburn - Nature Reviews Cancer, 2017 - nature.com
Autophagy is a mechanism by which cellular material is delivered to lysosomes for
degradation, leading to the basal turnover of cell components and providing energy and …