[HTML][HTML] Autophagy dysfunctions associated with cancer cells and their therapeutic implications
A Udristioiu, D Nica-Badea - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Genomic analysis of human cancers indicates that the loss or mutation of core autophagy
related genes,(ATG) is uncommon, whereas oncogenic events that activate autophagy and …
related genes,(ATG) is uncommon, whereas oncogenic events that activate autophagy and …
Understanding the role of autophagy in cancer formation and progression is a real opportunity to treat and cure human cancers
Simple Summary The modulation of autophagy represents a potential therapeutic strategy
for cancer. More than one hundred clinical trials have been conducted or are ongoing to …
for cancer. More than one hundred clinical trials have been conducted or are ongoing to …
Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications
Z Bai, Y Peng, X Ye, Z Liu, Y Li, L Ma - Journal of Zhejiang University …, 2022 - Springer
Cancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer
treatment, but the complex biological processes of cancer cells seriously limit the efficacy of …
treatment, but the complex biological processes of cancer cells seriously limit the efficacy of …
Autophagy as a molecular target for cancer treatment
Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …
Recent update and drug target in molecular and pharmacological insights into autophagy modulation in cancer treatment and future progress
Recent evidence suggests that autophagy is a governed catabolic framework enabling the
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …
Autophagy in tumor suppression and cancer therapy
CP Kung, A Budina, G Balaburski… - Critical Reviews™ in …, 2011 - dl.begellhouse.com
Autophagy is a stress-induced cell survival program whereby cells under metabolic,
proteotoxic, or other stress remove dysfunctional organelles and/or misfolded …
proteotoxic, or other stress remove dysfunctional organelles and/or misfolded …
Molecular machinery of autophagy and its implication in cancer
Y Li, J Zhang, T Liu, Y Chen, X Zeng, X Chen… - The American journal of …, 2012 - Elsevier
Autophagy is an intracellular lysosome-dependent catabolic process that is indispensable
for maintaining cellular homeostasis through the turnover and elimination of defective or …
for maintaining cellular homeostasis through the turnover and elimination of defective or …
Autophagy regulators in cancer
Autophagy plays a complex impact role in tumor initiation and development. It serves as a
double-edged sword by supporting cell survival in certain situations while also triggering …
double-edged sword by supporting cell survival in certain situations while also triggering …
Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics
Autophagy in cancer is an intensely debated concept in the field of translational research.
The dual nature of autophagy implies that it can potentially modulate the pro-survival and …
The dual nature of autophagy implies that it can potentially modulate the pro-survival and …
[HTML][HTML] Dual roles of autophagy and their potential drugs for improving cancer therapeutics
DW Shin - Biomolecules & Therapeutics, 2020 - ncbi.nlm.nih.gov
Autophagy is a major catabolic process that maintains cell metabolism by degrading
damaged organelles and other dysfunctional proteins via the lysosome. Abnormal …
damaged organelles and other dysfunctional proteins via the lysosome. Abnormal …