Genomic analysis of human cancers indicates that the loss or mutation of core autophagy
related genes,(ATG) is uncommon, whereas oncogenic events that activate autophagy and …

Simple Summary The modulation of autophagy represents a potential therapeutic strategy
for cancer. More than one hundred clinical trials have been conducted or are ongoing to …

Cancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer
treatment, but the complex biological processes of cancer cells seriously limit the efficacy of …

Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

Recent evidence suggests that autophagy is a governed catabolic framework enabling the
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …

Autophagy is a stress-induced cell survival program whereby cells under metabolic,
proteotoxic, or other stress remove dysfunctional organelles and/or misfolded …

Autophagy is an intracellular lysosome-dependent catabolic process that is indispensable
for maintaining cellular homeostasis through the turnover and elimination of defective or …

Autophagy plays a complex impact role in tumor initiation and development. It serves as a
double-edged sword by supporting cell survival in certain situations while also triggering …

Autophagy in cancer is an intensely debated concept in the field of translational research.
The dual nature of autophagy implies that it can potentially modulate the pro-survival and …

Autophagy is a major catabolic process that maintains cell metabolism by degrading
damaged organelles and other dysfunctional proteins via the lysosome. Abnormal …