[HTML][HTML] Autophagy modulators in cancer therapy

K Buzun, A Gornowicz, R Lesyk, K Bielawski… - International Journal of …, 2021 - mdpi.com
Autophagy is a process of self-degradation that plays an important role in removing
damaged proteins, organelles or cellular fragments from the cell. Under stressful conditions …

Understanding autophagy in cell death control

F Platini, R Perez-Tomas, S Ambrosio… - Current …, 2010 - ingentaconnect.com
Autophagy is an evolutionarily conserved degradation pathway which primary functions as a
cell survival adaptive mechanism during stress conditions. Autophagy is a tumor suppressor …

Autophagy as a molecular target for cancer treatment

NM Kocaturk, Y Akkoc, C Kig, O Bayraktar… - European Journal of …, 2019 - Elsevier
Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

[HTML][HTML] Autophagy dysfunctions associated with cancer cells and their therapeutic implications

A Udristioiu, D Nica-Badea - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Genomic analysis of human cancers indicates that the loss or mutation of core autophagy
related genes,(ATG) is uncommon, whereas oncogenic events that activate autophagy and …

Cell survival and cell death at the intersection of autophagy and apoptosis: Implications for current and future cancer therapeutics

N Bata, NDP Cosford - ACS pharmacology & translational science, 2021 - ACS Publications
Autophagy and apoptosis are functionally distinct mechanisms for cytoplasmic and cellular
turnover. While these two pathways are distinct, they can also regulate each other, and …

Autophagy: Molecular mechanisms and their implications for anticancer therapies

S Meschini, M Condello, P Lista… - Current cancer drug …, 2011 - ingentaconnect.com
Autophagy is a catabolic process whereby cells maintain homeostasis by eliminating
unnecessary proteins and damaged organelles. It may be triggered under physiological …

Autophagy and cancer: Basic mechanisms and inhibitor development

Y Hama, Y Ogasawara, NN Noda - Cancer Science, 2023 - Wiley Online Library
Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …

Pharmacological inhibitors of autophagy as novel cancer therapeutic agents

C Wang, Q Hu, HM Shen - Pharmacological research, 2016 - Elsevier
Autophagy is an evolutionarily conserved cellular degradative process in which intracellular
components (cellular proteins and organelles) are engulfed in autophagosomes which then …

Autophagy regulators as potential cancer therapeutic agents: a review

S Li, L Wang, Y Hu, R Sheng - Current topics in medicinal …, 2015 - ingentaconnect.com
Autophagy is an important basic metabolic mechanism by engulfing and degrading the
unnecessary or dysfunctional cellular components within double-membered autolysosomes …

Molecular machinery of autophagy and its implication in cancer

Y Li, J Zhang, T Liu, Y Chen, X Zeng, X Chen… - The American journal of …, 2012 - Elsevier
Autophagy is an intracellular lysosome-dependent catabolic process that is indispensable
for maintaining cellular homeostasis through the turnover and elimination of defective or …