Over the last two decades candidate gene association studies and genome-wide linkage
scans have met with little success in characterizing risk variants for hypertension. Several …

Among the common complex diseases, hypertension has been particularly unlucky in the
recent surge of positive results from genome-wide association studies. We summarize the …

Contemporary genomic tools now allow the fast and reliable genotyping of hundreds of
thousands of variants and permit an unbiased interrogation of the common variability across …

Hypertension continues to be a major risk factor for global mortality, and recent genome-
wide association studies (GWAS) have expanded in size, leading to the identification of …

Hypertension is a major risk factor for global mortality. Recent genome‐wide association
studies (GWAS) have led to successful identification of many genetic loci influencing blood …

Despite its significant genetic component, the study of hypertension by genome‐wide
association presents more challenges than other common complex diseases. Its high …

Genes and environmental factors contribute to an individual's risk of hypertension. Recent
advances in DNA sequencing technology have enabled the discovery of new causative …

Over the past few years, it has been asserted that genome-wide association studies would
open the door to identifying primary genetic mechanisms underlying a variety of common …

Recent advances in genotyping technology and in particular a number of large-scale
genome-wide association studies have helped to unravel the genetic basis of hypertension …

Cardiovascular diseases are the leading cause of death worldwide. Essential hypertension
is a major risk factor for the development of other cardiovascular diseases and is caused by …