Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells
Resistance of cancer cells to chemotherapy is a significant problem in oncology and the
development of sensitising agents or small-molecules with new mechanisms of action to kill …
development of sensitising agents or small-molecules with new mechanisms of action to kill …
Autophagy and its potent modulators from phytochemicals in cancer treatment
CY Sun, QY Zhang, GJ Zheng, B Feng - Cancer chemotherapy and …, 2019 - Springer
Autophagy is a ubiquitous catabolic process by which damaged or harmful intracellular
components are delivered to the lysosomes for self-digestion and recycling. It is critical in …
components are delivered to the lysosomes for self-digestion and recycling. It is critical in …
Phytochemicals as potent modulators of autophagy for cancer therapy
MA Moosavi, A Haghi, M Rahmati, H Taniguchi… - Cancer Letters, 2018 - Elsevier
The dysregulation of autophagy is involved in the pathogenesis of a broad range of
diseases, and accordingly universal research efforts have focused on exploring novel …
diseases, and accordingly universal research efforts have focused on exploring novel …
Autophagy in cancer: regulation by small molecules
AS Limpert, LJ Lambert, NA Bakas, N Bata… - Trends in …, 2018 - cell.com
During times of stress, autophagy is a cellular process that enables cells to reclaim
damaged components by a controlled recycling pathway. This mechanism for cellular …
damaged components by a controlled recycling pathway. This mechanism for cellular …
Seeking new anti-cancer agents from autophagy-regulating natural products
F Hua, S Shang, ZW Hu - Journal of Asian natural products …, 2017 - Taylor & Francis
Natural products are an important original source of many widely used drugs, including anti-
cancer drugs. Early research efforts for seeking anti-cancer therapy from the natural …
cancer drugs. Early research efforts for seeking anti-cancer therapy from the natural …
Targeting autophagy with natural products as a potential therapeutic approach for cancer
MAA Al-Bari, Y Ito, S Ahmed, N Radwan… - International journal of …, 2021 - mdpi.com
Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-
digestion caused by lysosomes on demand, which is upregulated as a survival strategy …
digestion caused by lysosomes on demand, which is upregulated as a survival strategy …
Natural compounds from herbs that can potentially execute as autophagy inducers for cancer therapy
SR Lin, YS Fu, MJ Tsai, H Cheng, CF Weng - International Journal of …, 2017 - mdpi.com
Accumulated evidence indicates that autophagy is a response of cancer cells to various anti-
cancer therapies. Autophagy is designated as programmed cell death type II, and is …
cancer therapies. Autophagy is designated as programmed cell death type II, and is …
Phytochemicals as a complement to cancer chemotherapy: pharmacological modulation of the autophagy-apoptosis pathway
Bioactive plant derived compounds are important for a wide range of therapeutic
applications, and some display promising anticancer properties. Further evidence suggests …
applications, and some display promising anticancer properties. Further evidence suggests …
Pharmacological inhibitors of autophagy as novel cancer therapeutic agents
Autophagy is an evolutionarily conserved cellular degradative process in which intracellular
components (cellular proteins and organelles) are engulfed in autophagosomes which then …
components (cellular proteins and organelles) are engulfed in autophagosomes which then …
Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy
J Zhang, G Wang, Y Zhou, Y Chen, L Ouyang… - Cellular and Molecular …, 2018 - Springer
Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process for the
clearance of damaged or superfluous proteins and organelles. Accumulating studies have …
clearance of damaged or superfluous proteins and organelles. Accumulating studies have …