Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells

BYK Law, WK Chan, SW Xu, JR Wang, LP Bai, L Liu… - Scientific reports, 2014 - nature.com
Resistance of cancer cells to chemotherapy is a significant problem in oncology and the
development of sensitising agents or small-molecules with new mechanisms of action to kill …

Autophagy and its potent modulators from phytochemicals in cancer treatment

CY Sun, QY Zhang, GJ Zheng, B Feng - Cancer chemotherapy and …, 2019 - Springer
Autophagy is a ubiquitous catabolic process by which damaged or harmful intracellular
components are delivered to the lysosomes for self-digestion and recycling. It is critical in …

Phytochemicals as potent modulators of autophagy for cancer therapy

MA Moosavi, A Haghi, M Rahmati, H Taniguchi… - Cancer Letters, 2018 - Elsevier
The dysregulation of autophagy is involved in the pathogenesis of a broad range of
diseases, and accordingly universal research efforts have focused on exploring novel …

Autophagy in cancer: regulation by small molecules

AS Limpert, LJ Lambert, NA Bakas, N Bata… - Trends in …, 2018 - cell.com
During times of stress, autophagy is a cellular process that enables cells to reclaim
damaged components by a controlled recycling pathway. This mechanism for cellular …

Seeking new anti-cancer agents from autophagy-regulating natural products

F Hua, S Shang, ZW Hu - Journal of Asian natural products …, 2017 - Taylor & Francis
Natural products are an important original source of many widely used drugs, including anti-
cancer drugs. Early research efforts for seeking anti-cancer therapy from the natural …

Targeting autophagy with natural products as a potential therapeutic approach for cancer

MAA Al-Bari, Y Ito, S Ahmed, N Radwan… - International journal of …, 2021 - mdpi.com
Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-
digestion caused by lysosomes on demand, which is upregulated as a survival strategy …

Natural compounds from herbs that can potentially execute as autophagy inducers for cancer therapy

SR Lin, YS Fu, MJ Tsai, H Cheng, CF Weng - International Journal of …, 2017 - mdpi.com
Accumulated evidence indicates that autophagy is a response of cancer cells to various anti-
cancer therapies. Autophagy is designated as programmed cell death type II, and is …

Phytochemicals as a complement to cancer chemotherapy: pharmacological modulation of the autophagy-apoptosis pathway

MA Rahman, MA Hannan, R Dash… - Frontiers in …, 2021 - frontiersin.org
Bioactive plant derived compounds are important for a wide range of therapeutic
applications, and some display promising anticancer properties. Further evidence suggests …

Pharmacological inhibitors of autophagy as novel cancer therapeutic agents

C Wang, Q Hu, HM Shen - Pharmacological research, 2016 - Elsevier
Autophagy is an evolutionarily conserved cellular degradative process in which intracellular
components (cellular proteins and organelles) are engulfed in autophagosomes which then …

Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy

J Zhang, G Wang, Y Zhou, Y Chen, L Ouyang… - Cellular and Molecular …, 2018 - Springer
Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process for the
clearance of damaged or superfluous proteins and organelles. Accumulating studies have …