Observational studies exploring whether there is a nonlinear effect of blood pressure on
cardiovascular disease (CVD) risk are hindered by confounding. This limitation can be …

This study aims to evaluate the causal association of blood pressure (BP) with
cardiovascular diseases (CVDs). Two-sample Mendelian randomization was performed …

Recent genome-wide association studies have identified genetic variants associated with
blood pressure (BP). We investigated whether genetic risk scores (GRSs) constructed of …

Importance Hypertension remains the major cardiovascular disease risk factor globally, but
variability in measured blood pressure may result in suboptimal management. Whether …

Hypertension is a major risk factor for cardiovascular disease and mortality. To identify
targets for the prevention of hypertension and its associated disease burden, we used the 2 …

Background: Recent clinical guidelines support intensive blood pressure treatment targets.
However, observational data suggest that excessive diastolic blood pressure (DBP) …

Hypertension is a risk factor for coronary artery disease. Recent genome-wide association
studies have identified 30 genetic variants associated with higher blood pressure at genome …

Objective We employed Mendelian randomization to explore whether the effects of blood
pressure (BP) and BP-lowering through different antihypertensive drug classes on stroke …

Genome-wide association analysis advanced understanding of blood pressure (BP), a
major risk factor for vascular conditions such as coronary heart disease and stroke …

Objective: We aimed to estimate the effect of blood pressure (BP) traits and BP-lowering
medications (via genetic proxies) on peripheral artery disease. Approach and Results …