[HTML][HTML] Amino acid reduction can help to improve the identification of antimicrobial peptides and their functional activities

GF Dong, L Zheng, SH Huang, J Gao, YC Zuo - Frontiers in Genetics, 2021 - frontiersin.org
Antimicrobial peptides (AMPs) are considered as potential substitutes of antibiotics in the
field of new anti-infective drug design. There have been several machine learning …

[HTML][HTML] Antimicrobial peptides: an update on classifications and databases

A Bin Hafeez, X Jiang, PJ Bergen, Y Zhu - International journal of …, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …

[HTML][HTML] Leveraging family-specific signatures for AMP discovery and high-throughput annotation

FH Waghu, RS Barai, S Idicula-Thomas - Scientific reports, 2016 - nature.com
Antimicrobial peptides (AMPs) are diverse, biologically active, essential components of the
innate immune system. As compared to conventional antibiotics, AMPs exhibit broad …

Predicting antimicrobial peptides by using increment of diversity with quadratic discriminant analysis method

P Feng, Z Wang, X Yu - IEEE/ACM Transactions on …, 2017 - ieeexplore.ieee.org
Antimicrobial peptides are crucial components of the innate host defense system of most
living organisms and promising candidates for antimicrobial agents. Accurate classification …

AMAP: Hierarchical multi-label prediction of biologically active and antimicrobial peptides

S Gull, N Shamim, F Minhas - Computers in biology and medicine, 2019 - Elsevier
Due to increase in antibiotic resistance in recent years, development of efficient and
accurate techniques for discovery and design of biologically active peptides such as …

Rational design of antimicrobial peptides: an optimization approach

D Sadasivam, P Nambiar, A Dutta… - Molecular Systems Design …, 2024 - pubs.rsc.org
With increasing concerns over antimicrobial resistance worldwide, antimicrobial peptides
(AMPs) can be a potential alternative to conventional antibiotics. Generating new AMPs is …

Tools in the era of multidrug resistance in bacteria: Applications for new antimicrobial peptides discovery

A Moretta, C Scieuzo, R Salvia… - Current …, 2022 - ingentaconnect.com
Antimicrobial peptides (AMPs) are small molecules belonging to innate immunity that act
against bacteria, fungi, and viruses. With the spread of bacterial strains resistant to current …

Comprehensive comparison of twenty structural characterization scales applied as QSAM of antimicrobial dodecapeptides derived from Bac2A against P. aeruginosa

Y Qian, W Liu, G Liang - Journal of Molecular Graphics and Modelling, 2017 - Elsevier
Informative numerical characterizations of amino acid residues are essential for quantitative
sequence-activity modeling (QSAM). To date, a variety of structural characterization methods …

[HTML][HTML] CS-AMPPred: an updated SVM model for antimicrobial activity prediction in cysteine-stabilized peptides

WF Porto, ÁS Pires, OL Franco - PLoS One, 2012 - journals.plos.org
The antimicrobial peptides (AMP) have been proposed as an alternative to control resistant
pathogens. However, due to multifunctional properties of several AMP classes, until now …

Artificial intelligence-driven antimicrobial peptide discovery

P Szymczak, E Szczurek - Current Opinion in Structural Biology, 2023 - Elsevier
Antimicrobial peptides (AMPs) emerge as promising agents against antimicrobial resistance,
providing an alternative to conventional antibiotics. Artificial intelligence (AI) revolutionized …