E-CLEAP: An ensemble learning model for efficient and accurate identification of antimicrobial peptides

SC Wang - Plos one, 2024 - journals.plos.org
With the increasing problem of antimicrobial drug resistance, the search for new
antimicrobial agents has become a crucial task in the field of medicine. Antimicrobial …

An efficient evaluation system accelerates α-helical antimicrobial peptide discovery and its application to global human genome mining

L Liu, C Wang, M Zhang, Z Zhang, Y Wu… - Frontiers in …, 2022 - frontiersin.org
Antimicrobial peptides (AMPs), as an important part of the innate immune system of an
organism, is a kind of promising drug candidate for novel antibiotics due to their unique …

Peptide array based discovery of synthetic antimicrobial peptides

CW Diehnelt - Frontiers in microbiology, 2013 - frontiersin.org
The rise of antibiotic resistance has emphasized the shortcomings in antibiotic drug
development (Boucher et al., 2013). The move from biological based discovery methods to …

Optimization of antibacterial peptides by genetic algorithms and cheminformatics

CD Fjell, H Jenssen, WA Cheung… - Chemical biology & …, 2011 - Wiley Online Library
Pathogens resistant to available drug therapies are a pressing global health problem. Short,
cationic peptides represent a novel class of agents that have lower rates of drug resistance …

AniAMPpred: artificial intelligence guided discovery of novel antimicrobial peptides in animal kingdom

R Sharma, S Shrivastava, S Kumar Singh… - Briefings in …, 2021 - academic.oup.com
With advancements in genomics, there has been substantial reduction in the cost and time
of genome sequencing and has resulted in lot of data in genome databases. Antimicrobial …

Creation of new antimicrobial peptides

OV Galzitskaya - International Journal of Molecular Sciences, 2023 - mdpi.com
Antimicrobial peptides (AMPs) are natural compounds that exhibit potent antimicrobial
activity against various microorganisms, including bacteria, fungi, and viruses. However, the …

Structure–activity predictions from computational mining of protein databases to assist modular design of antimicrobial peptides

C Feurstein, V Meyer, S Jung - Frontiers in Microbiology, 2022 - frontiersin.org
Antimicrobial peptides (AMPs) are naturally produced by pro-and eukaryotes and are
promising alternatives to antibiotics to fight multidrug-resistant microorganisms. However …

Computer-aided design of antimicrobial peptides: are we generating effective drug candidates?

MH Cardoso, RQ Orozco, SB Rezende… - Frontiers in …, 2020 - frontiersin.org
Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely
investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally …

Antimicrobial peptide resistance and scope of computational biology in antimicrobial peptide research

CKV Ramesan, NV Vinod, S Skariyachan - Antimicrobial Peptides, 2023 - Elsevier
The different antimicrobial peptides (AMPs) isolated from various sources vary in their amino
acid numbers and net charge, are recognized by nucleic acid sequencing. Since the …

AMPFinder: A computational model to identify antimicrobial peptides and their functions based on sequence-derived information

S Yang, Z Yang, X Ni - Analytical Biochemistry, 2023 - Elsevier
Antimicrobial peptides (AMPs) called host defense peptides have existed among all classes
of life with 5–100 amino acids generally and can kill mycobacteria, envelop viruses …