Whole-genome analyses reveal gene content differences between nontypeable Haemophilus influenzae isolates from chronic obstructive pulmonary disease …

R Kc, KWC Leong, NM Harkness… - Microbial …, 2020 - microbiologyresearch.org
Nontypeable Haemophilus influenzae (NTHi) colonizes human upper respiratory airways
and plays a key role in the course and pathogenesis of acute exacerbations of chronic …

Haemophilus influenzae genome evolution during persistence in the human airways in chronic obstructive pulmonary disease

MM Pettigrew, CP Ahearn, JF Gent… - Proceedings of the …, 2018 - National Acad Sciences
Nontypeable Haemophilus influenzae (NTHi) exclusively colonize and infect humans and
are critical to the pathogenesis of chronic obstructive pulmonary disease (COPD). In vitro …

[HTML][HTML] Nontypeable Haemophilus influenzae Genetic Islands Associated with Chronic Pulmonary Infection

L Zhang, J Xie, M Patel, A Bakhtyar, GD Ehrlich… - 2012 - journals.plos.org
Background Haemophilus influenzae (Hi) colonizes the human respiratory tract and is an
important pathogen associated with chronic obstructive pulmonary disease (COPD) …

Adaptation of Nontypeable Haemophilus influenzae in Human Airways in COPD: Genome Rearrangements and Modulation of Expression of HMW1 and HMW2

TF Murphy, C Kirkham, A D'Mello, S Sethi… - Mbio, 2023 - Am Soc Microbiol
Chronic obstructive pulmonary disease (COPD) is a common debilitating disorder that is the
third most common cause of death globally. Chronic lower airway infection by nontypeable …

Genotypic and phenotypic diversity of the noncapsulated Haemophilus influenzae: adaptation and pathogenesis in the human airways

J Garmendia, P Martí-Lliteras, J Moleres, C Puig… - 2012 - digital.csic.es
The human respiratory tract contains a highly adapted microbiota including commensal and
opportunistic pathogens. Noncapsulated or nontypable Haemophilus influenzae (NTHi) is a …

[HTML][HTML] Molecular Signatures of Non-typeable Haemophilus influenzae Lung Adaptation in Pediatric Chronic Lung Disease

A Aziz, DS Sarovich, E Nosworthy… - Frontiers in …, 2019 - frontiersin.org
Non-typeable Haemophilus influenzae (NTHi), an opportunistic pathogen of the upper
airways of healthy children, can infect the lower airways, driving chronic lung disease …

Discovery and contribution of nontypeable Haemophilus influenzae NTHI1441 to human respiratory epithelial cell invasion

CP Ahearn, C Kirkham, LD Chaves, Y Kong… - Infection and …, 2019 - Am Soc Microbiol
ABSTRACT Nontypeable Haemophilus influenzae (NTHi) is the primary cause of bacterially
induced acute exacerbations of chronic obstructive pulmonary disease (COPD). NTHi …

[HTML][HTML] Characterization of Nontypable Haemophilus influenzae Isolates Recovered from Adult Patients with Underlying Chronic Lung Disease Reveals Genotypic …

J Garmendia, C Viadas, L Calatayud, JC Mell… - PloS one, 2014 - journals.plos.org
Nontypable Haemophilus influenzae (NTHi) has emerged as an important opportunistic
pathogen causing infection in adults suffering obstructive lung diseases. Existing evidence …

Comparative Genomic Analysis of Non-typeable Haemophilus Influenzae in Children with Acute and Chronic Pneumonia versus Healthy Controls

DM Zhang, W Wang, C Song, T Huang, H Chen, Z Liu… - medRxiv, 2024 - medrxiv.org
Non-typeable Hemophilus Influenzae (NTHi) is a common pathogen that can cause a range
of respiratory infections, including children pneumonia. However, NTHi can also be found in …

Genome sequencing of disease and carriage isolates of nontypeable Haemophilus influenzae identifies discrete population structure

M De Chiara, D Hood, A Muzzi… - Proceedings of the …, 2014 - National Acad Sciences
One of the main hurdles for the development of an effective and broadly protective vaccine
against nonencapsulated isolates of Haemophilus influenzae (NTHi) lies in the genetic …