Due to the heterogeneity of soft tissue sarcomas (STS), the choice of the proper
perioperative treatment regimen is challenging. Neoadjuvant therapy has attracted …

Soft tissue sarcomas are a rare and multifaceted group of solid tumours. Neoadjuvant
chemotherapy is increasingly used to limit loss of function after wide surgical excision with …

Background The prognostic role of tumor necrosis following neoadjuvant therapy is
established in bone sarcomas but remains unclear in soft tissue sarcomas (STS). Methods …

At present, there is not a commonly used and generally accepted standardized approach for
the pathologic evaluation of pretreated soft tissue sarcomas. Also, it is still unclear whether …

Purpose Sarcomas are a rare and heterogeneous variant of cancer. The standard of care
treatment involves surgical resection with radiation in high-risk patients. Despite appropriate …

Together with surgery and radiotherapy, systemic treatment with cytotoxic chemotherapy
and molecular targeted agents is one of the main therapeutic pillars in the treatment of soft …

Background The role of chemotherapy in high-risk soft tissue sarcoma is controversial.
Though many patients undergo initial curative resection, distant metastasis is a frequent …

Primary therapy for soft tissue sarcoma is predicated on surgical resection with an adequate
margin of normal tissue. For high-risk patients, local control is improved with postoperative …

PURPOSE To determine whether the administration of histology-tailored neoadjuvant
chemotherapy (HT) was superior to the administration of standard anthracycline plus …

Soft tissue sarcomas (STS) represent a broad family of rare tumours for which surgery with
radiotherapy represents first-line treatment. Recently, neoadjuvant chemo-radiotherapy has …