Targeting autophagy using natural compounds for cancer prevention and therapy

S Deng, MK Shanmugam, AP Kumar, CT Yap, G Sethi… - Cancer, 2019 - Wiley Online Library
Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

Autophagy inducers in cancer

M Russo, GL Russo - Biochemical pharmacology, 2018 - Elsevier
Autophagy is a complex, physiological process devoted to degrade and recycle cellular
components. Proteins and organelles are first phagocytized by autophagosomes, then …

Molecular insights into the multifunctional role of natural compounds: autophagy modulation and cancer prevention

MA Rahman, MDH Rahman, MS Hossain, P Biswas… - Biomedicines, 2020 - mdpi.com
Autophagy is a vacuolar, lysosomal degradation pathway for injured and damaged protein
molecules and organelles in eukaryotic cells, which is controlled by nutrients and stress …

Phytochemicals as potent modulators of autophagy for cancer therapy

MA Moosavi, A Haghi, M Rahmati, H Taniguchi… - Cancer Letters, 2018 - Elsevier
The dysregulation of autophagy is involved in the pathogenesis of a broad range of
diseases, and accordingly universal research efforts have focused on exploring novel …

Therapeutic targeting of autophagy in disease: biology and pharmacology

Y Cheng, X Ren, WN Hait, JM Yang - Pharmacological reviews, 2013 - ASPET
Autophagy, a process of self-digestion of the cytoplasm and organelles through which
cellular components are recycled for reuse or energy production, is an evolutionarily …

New visions on natural products and cancer therapy: autophagy and related regulatory pathways

A Martelli, M Omrani, M Zarghooni, V Citi, S Brogi… - Cancers, 2022 - mdpi.com
Simple Summary In the past few years, clinical as well as regular scientists have been
paying attention to medicinal applications of natural products. There are several …

Autophagy modulation as a target for anticancer drug discovery

X Li, H Xu, Y Liu, N An, S Zhao, J Bao - Acta Pharmacologica Sinica, 2013 - nature.com
Autophagy, an evolutionarily conserved catabolic process involving the engulfment and
degradation of non-essential or abnormal cellular organelles and proteins, is crucial for …

Autophagy in cancer: regulation by small molecules

AS Limpert, LJ Lambert, NA Bakas, N Bata… - Trends in …, 2018 - cell.com
During times of stress, autophagy is a cellular process that enables cells to reclaim
damaged components by a controlled recycling pathway. This mechanism for cellular …

Pharmacological inhibitors of autophagy as novel cancer therapeutic agents

C Wang, Q Hu, HM Shen - Pharmacological research, 2016 - Elsevier
Autophagy is an evolutionarily conserved cellular degradative process in which intracellular
components (cellular proteins and organelles) are engulfed in autophagosomes which then …

Autophagy: The spotlight for cellular stress responses

P Ravanan, IF Srikumar, P Talwar - Life sciences, 2017 - Elsevier
Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal
physiological processes including removing of long lived, aggregated and misfolded …