[PDF][PDF] Transcriptional dynamics of hepatic sinusoidassociated cells after liver injury
MK Terkelsen, SM Bendixen, D Hansen… - …, 2020 - Wiley Online Library
Background and Aims Hepatic sinusoidal cells are known actors in the fibrogenic response
to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and …
to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and …
[HTML][HTML] Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis
R Dobie, JR Wilson-Kanamori, BEP Henderson… - Cell reports, 2019 - cell.com
Iterative liver injury results in progressive fibrosis disrupting hepatic architecture,
regeneration potential, and liver function. Hepatic stellate cells (HSCs) are a major source of …
regeneration potential, and liver function. Hepatic stellate cells (HSCs) are a major source of …
[HTML][HTML] Heterogeneity of hepatic stellate cells in fibrogenesis of the liver: insights from single-cell transcriptomic analysis in liver injury
W Zhang, SJ Conway, Y Liu, P Snider, H Chen, H Gao… - Cells, 2021 - mdpi.com
Background & Aims: Liver fibrosis is a pathological healing process resulting from hepatic
stellate cell (HSC) activation and the generation of myofibroblasts from activated HSCs. The …
stellate cell (HSC) activation and the generation of myofibroblasts from activated HSCs. The …
[HTML][HTML] How to face chronic liver disease: the sinusoidal perspective
A Fernandez-Iglesias, J Gracia-Sancho - Frontiers in medicine, 2017 - frontiersin.org
Liver microcirculation plays an essential role in the progression and aggravation of chronic
liver disease. Hepatic sinusoid environment, mainly composed by hepatocytes, liver …
liver disease. Hepatic sinusoid environment, mainly composed by hepatocytes, liver …
[PDF][PDF] Singlecell transcriptomic analysis reveals a hepatic stellate cell–activation roadmap and myofibroblast origin during liver fibrosis in mice
Background and Aims HSCs and portal fibroblasts (PFs) are the major sources of collagen
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …
[HTML][HTML] Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis
Background Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the
progression of liver fibrosis and cirrhosis and responsible for its clinical complications. Here …
progression of liver fibrosis and cirrhosis and responsible for its clinical complications. Here …
[HTML][HTML] Transcriptional regulation of Hepatic Stellate Cell activation in NASH
AB Marcher, SM Bendixen, MK Terkelsen… - Scientific reports, 2019 - nature.com
Non-alcoholic steatohepatitis (NASH) signified by hepatic steatosis, inflammation,
hepatocellular injury, and fibrosis is a growing cause of chronic liver disease, cirrhosis, and …
hepatocellular injury, and fibrosis is a growing cause of chronic liver disease, cirrhosis, and …
[HTML][HTML] The crosstalk between liver sinusoidal endothelial cells and hepatic microenvironment in NASH related liver fibrosis
W Du, L Wang - Frontiers in Immunology, 2022 - frontiersin.org
Chronic liver injury can be caused by many factors, including virus infection, alcohol intake,
cholestasis and abnormal fat accumulation. Nonalcoholic steatohepatitis (NASH) has …
cholestasis and abnormal fat accumulation. Nonalcoholic steatohepatitis (NASH) has …
An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis
Advanced hepatic fibrosis, driven by the activation of hepatic stellate cells (HSCs), affects
millions worldwide and is the strongest predictor of mortality in nonalcoholic steatohepatitis …
millions worldwide and is the strongest predictor of mortality in nonalcoholic steatohepatitis …
[HTML][HTML] Capillarized liver sinusoidal endothelial cells undergo partial endothelial-mesenchymal transition to actively deposit sinusoidal ECM in liver fibrosis
B Ruan, JL Duan, H Xu, KS Tao, H Han… - Frontiers in Cell and …, 2021 - frontiersin.org
Tissue-specific endothelial cells are more than simply a barrier lining capillaries and are
proved to be capable of remarkable plasticity to become active collagen matrix-producing …
proved to be capable of remarkable plasticity to become active collagen matrix-producing …