The dystonias are comprised of a group of disorders that share common neurological
abnormalities of involuntary twisting or repetitive movements and postures. The most …

Background DYT1 dystonia is a heritable, early-onset generalized movement disorder
caused by a GAG deletion (ΔGAG) in the DYT1 gene. Neuroimaging studies and studies …

Presently, 17 distinct monogenic primary dystonias referred to as dystonias 1–4, 5a, b, 6–8,
10–13 and 15–18 (loci DYT 1–4, 5a, b, 6–8, 10–13, 15–18) have been recognized. Twelve …

Dystonia is a term used to describe a specific set of abnormal movements that can occur as
a symptom of a variety of neurologic disorders, but also as a disease entity in its own right …

Dystonia in childhood may be severely disabling and often unremitting and unrecognized.
Considered a rare disorder, dystonic symptoms in childhood are pervasive in many …

DYT1 dystonia is a hereditary neurologic movement disorder characterized by
uncontrollable muscle contractions. It is caused by a heterozygous mutation in Torsin A …

Projections from thalamic intralaminar nuclei convey sensory signals to striatal cholinergic
interneurons. These neurons respond with a pause in their pacemaking activity, enabling …

The torsion dystonias encompass a broad collection of etiologic subtypes, often divided into
primary and secondary classes. Over the last two decades an increasing number of genetic …

Animal and human brain-imaging studies have suggested a role for neurodevelopmental
abnormalities in the pathophysiology of dystonia. Variants in neurodevelopmental genes …

Dystonia is a neurological disorder characterized by abnormal involuntary movements that
are prolonged and often cause twisting and turning. Several genetically modified worms …