[HTML][HTML] The brain's glymphatic system: current controversies

H Mestre, Y Mori, M Nedergaard - Trends in neurosciences, 2020 - cell.com
The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in
recent years, highlighted that fluid is directionally transported within the central nervous …

The glymphatic system: implications for drugs for central nervous system diseases

TJ Lohela, TO Lilius, M Nedergaard - Nature Reviews Drug Discovery, 2022 - nature.com
In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …

The glymphatic system: a novel component of fundamental neurobiology

LM Hablitz, M Nedergaard - Journal of Neuroscience, 2021 - Soc Neuroscience
Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

[HTML][HTML] The glymphatic system: a new perspective on brain diseases

Z Ding, X Fan, Y Zhang, M Yao, G Wang… - Frontiers in Aging …, 2023 - frontiersin.org
The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …

[HTML][HTML] The glymphatic system and meningeal lymphatics of the brain: new understanding of brain clearance

G Yankova, O Bogomyakova… - Reviews in the …, 2021 - degruyter.com
The glymphatic system and meningeal lymphatics have recently been characterized.
Glymphatic system is a glia-dependent system of perivascular channels, and it plays an …

A clinical primer for the glymphatic system

LP Carlstrom, A Eltanahy, A Perry, AA Rabinstein… - Brain, 2022 - academic.oup.com
The complex and dynamic system of fluid flow through the perivascular and interstitial
spaces of the CNS has new-found implications for neurological diseases. CSF movement …

[HTML][HTML] Fluid dynamics in aging-related dementias

TM Bah, DA Siler, AH Ibrahim, JS Cetas… - Neurobiology of …, 2023 - Elsevier
Recent human and animal model experimental studies revealed novel pathways for fluid
movement, immune cell trafficking and metabolic waste clearance in CNS. These studies …

[HTML][HTML] The glymphatic system: Current understanding and modeling

T Bohr, PG Hjorth, SC Holst, S Hrabětová, V Kiviniemi… - IScience, 2022 - cell.com
We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

[HTML][HTML] Glymphatic system: an emerging therapeutic approach for neurological disorders

Y Gao, K Liu, J Zhu - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
The functions of the glymphatic system include clearance of the metabolic waste and
modulation of the water transport in the brain, and it forms a brain-wide fluid network along …

Current concepts in intracranial interstitial fluid transport and the glymphatic system: part II—imaging techniques and clinical applications

JM Klostranec, D Vucevic, KD Bhatia, HGJ Kortman… - Radiology, 2021 - pubs.rsna.org
The glymphatic system is a recently discovered network unique to the central nervous
system that allows for dynamic exchange of interstitial fluid (ISF) and cerebrospinal fluid …