BACKGROUND AND PURPOSE: Laser Doppler flowmetry (LDF) is increasingly used to
assess adequate occlusion after embolic stroke (ES) in rats. METHODS: Employing LDF …

Background Laser Doppler flowmetry (LDF) can reliably reflect brain perfusion in
experimental stroke by monitoring both the degree and the duration of relative regional …

Background Stroke is among the leading causes of death and disability. Although intense
research efforts have provided promising treatment options in animals, most clinical trials in …

Abstract Background Laser Doppler flowmetry (LDF) is widely used for estimating cerebral
blood flow changes during intraluminal middle cerebral artery occlusion (MCAO). No …

The translational potential of pre-clinical stroke research depends on the accuracy of
experimental modeling. Cerebral perfusion monitoring in animal models of acute ischemic …

Background We previously demonstrated that tissue plasminogen activator (tPA) reduces
infarct size after mechanical middle cerebral artery occlusion (MCAO) in wild-type (WT) mice …

Background and Purpose—The purpose of this study was to develop a novel MRI method
for imaging clot lysis in a rat embolic stroke model and to compare tissue plasminogen …

Laser Doppler fluxmetry (LDF) and electrocorticography (ECG) are techniques used to
indicate successful occlusion of the middle cerebral artery (MCAO) in the intraluminal …

Background—The duration of cerebral blood flow impairment correlates with irreversibility of
brain damage in animal models of cerebral ischemia. Our aim was to correlate clinical …

High variability in infarct size is common in experimental stroke models and affects statistical
power and validity of neuroprotection trials. The aim of this study was to explore cerebral …