Introduction: Vancomycin remains the reference antibiotic in neonates for care-related
infections caused by ß-lactam–resistant Gram-positive bacteria. Achieving the optimal serum …

Objective Because pharmacokinetic data are limited, continuous infusions of vancomycin in
neonates are administered using different dosing regimens. The aim of this work was to …

Objective To compare the effectiveness of intermittent and continuous vancomycin infusions
in achieving target concentrations in neonates and to assess the implications for clinical …

Aims Since vancomycin's bactericidal action has been shown to be time‐dependent, a
constant rate infusion over 24 h might result in a better bactericidal efficacy. The purpose of …

Background There is no consensus on vancomycin dosing in newborns and young infants.
Objective The first objective was to assess the efficiency of a simplified dosing regimen with …

Vancomycin dosing used in neonates results frequently in insufficient concentrations. A
vancomycin dose-optimization protocol consisting of an individualization of loading and …

We prospectively studied the pharmacokinetic parameters of vancomycin in premature
neonates given vancomycin according to a dosage protocol developed in our neonatal unit …

BACKGROUND: Vancomycin is recommended for optimal treatment of late-onset sepsis
caused by coagulase-negative Staphylococcus in neonates. OBJECTIVES: To assess the …

AIMS To design and evaluate dosing guidelines for vancomycin based on data collected
during routine use of the drug. METHODS Following the observation that 66% of neonatal …

Background Recently the value of vancomycin therapeutic drug monitoring, as well as the
required therapeutic range, has been subject of debate, resulting in new recommendations …