Background In the pediatric population, infections by methicillin-resistant Staphylococcus
aureus (MRSA) are associated with significant morbidity and hospital costs. Vancomycin is a …

Abstract Background/Purpose The aim of this study is to determine the best dosing strategy
for vancomycin by studying the associated factors and examining correlations between the …

Objective: To examine the impact of a new policy to ensure appropriate use of vancomycin
in a 461-bed tertiary-care hospital. Design: We instituted a policy that allowed physicians to …

Background: Particularly with the current increased vancomycin dosing trends, the true risk
of the agent's nephrotoxicity is not well characterized and remains of concern. Objective: To …

Background Anecdotal experience and studies have shown that most pediatric patients fail
to reach target therapeutic vancomycin trough levels (VTLs) and required higher total daily …

Background: Our objectives were to (1) determine the pharmacokinetic indices of
vancomycin in pediatric patients; and (2) compare attainment of 2 target exposures: area …

Background Vancomycin is a frequently used antibiotic in neonates. However, there is no
consensus guideline on the optimal dosing regimen and therapeutic drug monitoring (TDM) …

Objective: To describe the relationships between dosing strategy, age, and vancomycin
trough concentrations in pediatric patients. Methods: This is a retrospective review of …

Background Pediatric studies and anecdotal experience suggest that current empiric
vancomycin dosing does not reach serum trough concentration targets of at least 10 mg/L for …

Background: Despite its frequent use, the optimal dosing regimen of intravenous
vancomycin remains controversial. Achievement of therapeutic trough early in the course of …