Preclinical strategies for testing of targeted radiosensitizers

SH Lin, R Ye, Y Wang - Molecular Targeted Radiosensitizers …, 2020 - Springer
Use of radiation for cancer therapy began shortly after the discovery of X-rays in 1895.
Technological advances over the ensuing 120 years have enabled the development of …

Introduction to molecular targeted radiosensitizers: opportunities and challenges

H Willers, I Eke - Molecular Targeted Radiosensitizers: Opportunities …, 2020 - Springer
The practice of radiation oncology is currently primarily based on precise technical delivery
of highly conformal, image-guided radiation treatments. The precision medicine revolution …

[HTML][HTML] Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers

KJ Harrington, LJ Billingham, TB Brunner… - British journal of …, 2011 - nature.com
There is a growing appreciation of the potential value of combining novel molecularly-
targeted drugs with radiotherapy or chemoradiotherapy. Such approaches have the …

Opportunities and challenges in the era of molecularly targeted agents and radiation therapy

SH Lin, TJ George, E Ben-Josef… - Journal of the …, 2013 - academic.oup.com
The first annual workshop for preclinical and clinical development of radiosensitizers took
place at the National Cancer Institute on August 8–9, 2012. Radiotherapy is one of the most …

On the path to seeking novel radiosensitizers

D Katz, E Ito, FF Liu - International Journal of Radiation Oncology* Biology …, 2009 - Elsevier
Radiation therapy is a highly effective cancer treatment modality, and extensive
investigations have been undertaken over the years to augment its efficacy in the clinic. This …

Translating Targeted Radiosensitizers into the Clinic

DE Citrin, KA Camphausen - Molecular Targeted Radiosensitizers …, 2020 - Springer
Radiation therapy is commonly used in the curative treatment of cancer. Despite recent
progress in the techniques of radiation delivery and treatment, local recurrence after …

Preclinical in vivo evaluation of novel radiosensitizers by local tumor control experiments

K Schneider, N Ebert, I Kurth, M Baumann - … Opportunities and Challenges, 2020 - Springer
Over the past several years, significant technological and biological progress has been
made in radiation oncology with focus on the development of new treatment schemes to …

Molecular targeted radiosensitizers: opportunities and challenges

H Willers, I Eke - 2020 - books.google.com
Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader
with a comprehensive review of key pre-clinical research components required to identify …

NCI–RTOG translational program strategic guidelines for the early-stage development of radiosensitizers

YR Lawrence, B Vikram, JJ Dignam… - Journal of the …, 2013 - academic.oup.com
The addition of chemotherapeutic agents to ionizing radiation has improved survival in many
malignancies. Cure rates may be further improved by adding novel targeted agents to …

New radiosensitizing regimens, drugs, prodrugs, and candidates.

AK Vallerga, DA Zarling, TJ Kinsella - Clinical Advances in …, 2004 - europepmc.org
There have been significant advances over the last decade in the understanding of cellular,
biochemical, and molecular effects of ionizing radiation combined with certain types of …