The calcium/calmodulin-dependent kinases II and IV as therapeutic targets in neurodegenerative and neuropsychiatric disorders
K Sałaciak, A Koszałka, E Żmudzka… - International Journal of …, 2021 - mdpi.com
CaMKII and CaMKIV are calcium/calmodulin-dependent kinases playing a rudimentary role
in many regulatory processes in the organism. These kinases attract increasing interest due …
in many regulatory processes in the organism. These kinases attract increasing interest due …
Camkiiβ in neuronal development and plasticity: An emerging candidate in brain diseases
The calcium/calmodulin-dependent protein kinase II (CaMKII) is a ubiquitous and central
player in Ca2+ signaling that is best known for its functions in the brain. In particular, the α …
player in Ca2+ signaling that is best known for its functions in the brain. In particular, the α …
Emerging role of CaMKII in neuropsychiatric disease
AJ Robison - Trends in neurosciences, 2014 - cell.com
Although it has been known for decades that hippocampal calcium/calmodulin (CaM)-
dependent protein kinase II (CaMKII) plays an essential role in learning and memory …
dependent protein kinase II (CaMKII) plays an essential role in learning and memory …
Calcium/calmodulin-dependent protein kinase IV: A multifunctional enzyme and potential therapeutic target
The calcium/calmodulin-dependent protein kinase IV (CAMKIV) belongs to the
serine/threonine protein kinase family, and is primarily involved in transcriptional regulation …
serine/threonine protein kinase family, and is primarily involved in transcriptional regulation …
Molecular Mechanisms Underlying Ca2+/Calmodulin-Dependent Protein Kinase Kinase Signal Transduction
H Tokumitsu, H Sakagami - International journal of molecular sciences, 2022 - mdpi.com
Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) is the activating kinase for
multiple downstream kinases, including CaM-kinase I (CaMKI), CaM-kinase IV (CaMKIV) …
multiple downstream kinases, including CaM-kinase I (CaMKI), CaM-kinase IV (CaMKIV) …
Generation and behavior characterization of CaMKIIβ knockout mice
The calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain,
where it makes important contributions to synaptic organization and homeostasis, including …
where it makes important contributions to synaptic organization and homeostasis, including …
Neuronal CaMKII acts as a structural kinase
YC Lin, L Redmond - Communicative & integrative biology, 2009 - Taylor & Francis
CaMKII, calcium/calmodulin dependent protein kinase, is an active kinase in the cell that
phosphorylates a number of substrates including several cytoskeletal and signaling …
phosphorylates a number of substrates including several cytoskeletal and signaling …
Calcium‐/Calmodulin‐Dependent Protein Kinase II (CaMKII) Inhibition Induces Learning and Memory Impairment and Apoptosis
J Wang, X Xu, W Jia, D Zhao, T Boczek… - Oxidative Medicine …, 2021 - Wiley Online Library
Objectives. Inhibition of calcium‐/calmodulin‐(CaM‐) dependent kinase II (CaMKII) is
correlated with epilepsy. However, the specific mechanism that underlies learning and …
correlated with epilepsy. However, the specific mechanism that underlies learning and …
Transgenic up-regulation of alpha-CaMKII in forebrain leads to increased anxiety-like behaviors and aggression
S Hasegawa, T Furuichi, T Yoshida, K Endoh, K Kato… - Molecular brain, 2009 - Springer
Background Previous studies have demonstrated essential roles for alpha-
calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) in learning, memory and …
calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) in learning, memory and …
Calmodulin kinases: essential regulators in health and disease
S Takemoto‐Kimura, K Suzuki… - Journal of …, 2017 - Wiley Online Library
Neuronal activity induces intracellular Ca2+ increase, which triggers activation of a series of
Ca2+‐dependent signaling cascades. Among these, the multifunctional Ca2+/calmodulin …
Ca2+‐dependent signaling cascades. Among these, the multifunctional Ca2+/calmodulin …