Large collections of annotated cancer cell lines are powerful tools for precisely matching
targeted drugs with genomic alterations that can be tested as biomarkers in the clinic …

The development of molecular targeted drugs with radiation and chemotherapy is critically
important for improving the outcomes of patients with hard-to-treat, potentially curable …

The last two decades have seen technological developments that have led to more accurate
delivery of radiation therapy (RT), which has resulted in clinical gains in many solid tumors …

Photon radiation therapy is a major curative treatment for cancer. However, the lack of robust
predictive biomarkers for radiosensitivity precludes personalized radiation therapy …

Purpose: To review the many changes which have occurred in the past decades in the field
of predicting outcome after radiotherapy from biological characteristics of the tumour or …

Clonogenic assays evaluate the ability of single cells to proliferate and form colonies. This
process approximates the regrowth and recurrence of tumors after treatment with radiation …

Purpose: There is increasing interest in radiogenomics and the characterization of molecular
profiles that predict normal tissue and tumor radioresponse. A meeting in Amsterdam was …

Multiple transcriptomic predictors of tumour cell radiosensitivity (RS) have been proposed,
but they have not been benchmarked against one another or to control models. To address …

It is estimated that in 2008 1.4 million patients in North America will be diagnosed with a
nonskin form of cancer (www. cancer. org), of which seventy-five percent will receive …

Radiation therapy is used to treat half of all cancer patients. Response to radiation therapy
varies widely among patients. Therefore, we performed a genome-wide association study …