Clinical and molecular predictors of response and survival following venetoclax therapy in relapsed/refractory AML

M Stahl, K Menghrajani, A Derkach, A Chan… - Blood …, 2021 - ashpublications.org
Abstract Azacitidine+ venetoclax, decitabine+ venetoclax, and low-dose cytarabine+
venetoclax are now standard treatments for newly diagnosed older or unfit patients with …

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia

CD DiNardo, K Pratz, V Pullarkat… - Blood, The Journal …, 2019 - ashpublications.org
Older patients with acute myeloid leukemia (AML) respond poorly to standard induction
therapy. B-cell lymphoma 2 (BCL-2) overexpression is implicated in survival of AML cells …

Real-world experience of venetoclax with azacitidine for untreated patients with acute myeloid leukemia

AC Winters, JA Gutman, E Purev, M Nakic… - Blood …, 2019 - ashpublications.org
Venetoclax is approved for older untreated acute myeloid leukemia (AML) patients.
Venetoclax was available prior to approval off-label. We assessed our single-institution off …

Venetoclax with azacitidine or decitabine in patients with newly diagnosed acute myeloid leukemia: long term follow‐up from a phase 1b study

DA Pollyea, K Pratz, A Letai, BA Jonas… - American journal of …, 2021 - Wiley Online Library
This analysis represents the longest‐term follow‐up for patients with acute myeloid leukemia
(AML) treated with 400 mg of venetoclax plus azacitidine or decitabine. Adults with newly …

Venetoclax combined with low-dose cytarabine for previously untreated patients with acute myeloid leukemia: results from a phase Ib/II study

AH Wei, SA Strickland Jr, JZ Hou, W Fiedler… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE Effective treatment options are limited for patients with acute myeloid leukemia
(AML) who cannot tolerate intensive chemotherapy. An international phase Ib/II study …

Venetoclax combination therapy in relapsed/refractory acute myeloid leukemia: a single institution experience

D Gaut, A Burkenroad, T Duong, J Feammelli… - Leukemia Research, 2020 - Elsevier
Venetoclax (VEN) is a selective BCL-2 inhibitor that has been shown to be effective when
used in combination with hypomethylating agents (HMAs) or low-dose cytarabine (LDAC) for …

Long‐term follow‐up of VIALE‐A: Venetoclax and azacitidine in chemotherapy‐ineligible untreated acute myeloid leukemia

KW Pratz, BA Jonas, V Pullarkat… - American journal of …, 2024 - Wiley Online Library
Venetoclax‐azacitidine is approved for treatment of patients with newly diagnosed acute
myeloid leukemia (AML) ineligible for intensive chemotherapy based on the interim overall …

Phase II study of venetoclax added to cladribine plus low-dose cytarabine alternating with 5-azacitidine in older patients with newly diagnosed acute myeloid leukemia

TM Kadia, PK Reville, X Wang, CR Rausch… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE The combination of venetoclax and 5-azacitidine (5-AZA) for older or unfit
patients with acute myeloid leukemia (AML) improves remission rates and survival …

Treatment-free remission after ceasing venetoclax-based therapy in patients with acute myeloid leukemia

CC Chua, D Hammond, A Kent, IS Tiong… - Blood …, 2022 - ashpublications.org
The clinical benefit of adding venetoclax (VEN) to hypomethylating agents or low-dose
cytarabine in older and/or unfit patients with newly diagnosed acute myeloid leukemia (AML) …

[HTML][HTML] Venetoclax as monotherapy and in combination with hypomethylating agents or low dose cytarabine in relapsed and treatment refractory acute myeloid …

JP Bewersdorf, S Giri, R Wang, RT Williams… - …, 2020 - ncbi.nlm.nih.gov
Recent clinical data have shown a synergistic effect of venetoclax in combination with the
hypomethylating agents (HMA) azacitidine and decitabine (complete remission [CR]/CR with …