Clinical and molecular predictors of response and survival following venetoclax therapy in relapsed/refractory AML
Abstract Azacitidine+ venetoclax, decitabine+ venetoclax, and low-dose cytarabine+
venetoclax are now standard treatments for newly diagnosed older or unfit patients with …
venetoclax are now standard treatments for newly diagnosed older or unfit patients with …
Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia
CD DiNardo, K Pratz, V Pullarkat… - Blood, The Journal …, 2019 - ashpublications.org
Older patients with acute myeloid leukemia (AML) respond poorly to standard induction
therapy. B-cell lymphoma 2 (BCL-2) overexpression is implicated in survival of AML cells …
therapy. B-cell lymphoma 2 (BCL-2) overexpression is implicated in survival of AML cells …
Real-world experience of venetoclax with azacitidine for untreated patients with acute myeloid leukemia
AC Winters, JA Gutman, E Purev, M Nakic… - Blood …, 2019 - ashpublications.org
Venetoclax is approved for older untreated acute myeloid leukemia (AML) patients.
Venetoclax was available prior to approval off-label. We assessed our single-institution off …
Venetoclax was available prior to approval off-label. We assessed our single-institution off …
Venetoclax with azacitidine or decitabine in patients with newly diagnosed acute myeloid leukemia: long term follow‐up from a phase 1b study
This analysis represents the longest‐term follow‐up for patients with acute myeloid leukemia
(AML) treated with 400 mg of venetoclax plus azacitidine or decitabine. Adults with newly …
(AML) treated with 400 mg of venetoclax plus azacitidine or decitabine. Adults with newly …
Venetoclax combined with low-dose cytarabine for previously untreated patients with acute myeloid leukemia: results from a phase Ib/II study
AH Wei, SA Strickland Jr, JZ Hou, W Fiedler… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE Effective treatment options are limited for patients with acute myeloid leukemia
(AML) who cannot tolerate intensive chemotherapy. An international phase Ib/II study …
(AML) who cannot tolerate intensive chemotherapy. An international phase Ib/II study …
Venetoclax combination therapy in relapsed/refractory acute myeloid leukemia: a single institution experience
D Gaut, A Burkenroad, T Duong, J Feammelli… - Leukemia Research, 2020 - Elsevier
Venetoclax (VEN) is a selective BCL-2 inhibitor that has been shown to be effective when
used in combination with hypomethylating agents (HMAs) or low-dose cytarabine (LDAC) for …
used in combination with hypomethylating agents (HMAs) or low-dose cytarabine (LDAC) for …
Long‐term follow‐up of VIALE‐A: Venetoclax and azacitidine in chemotherapy‐ineligible untreated acute myeloid leukemia
Venetoclax‐azacitidine is approved for treatment of patients with newly diagnosed acute
myeloid leukemia (AML) ineligible for intensive chemotherapy based on the interim overall …
myeloid leukemia (AML) ineligible for intensive chemotherapy based on the interim overall …
Phase II study of venetoclax added to cladribine plus low-dose cytarabine alternating with 5-azacitidine in older patients with newly diagnosed acute myeloid leukemia
TM Kadia, PK Reville, X Wang, CR Rausch… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE The combination of venetoclax and 5-azacitidine (5-AZA) for older or unfit
patients with acute myeloid leukemia (AML) improves remission rates and survival …
patients with acute myeloid leukemia (AML) improves remission rates and survival …
Treatment-free remission after ceasing venetoclax-based therapy in patients with acute myeloid leukemia
CC Chua, D Hammond, A Kent, IS Tiong… - Blood …, 2022 - ashpublications.org
The clinical benefit of adding venetoclax (VEN) to hypomethylating agents or low-dose
cytarabine in older and/or unfit patients with newly diagnosed acute myeloid leukemia (AML) …
cytarabine in older and/or unfit patients with newly diagnosed acute myeloid leukemia (AML) …
[HTML][HTML] Venetoclax as monotherapy and in combination with hypomethylating agents or low dose cytarabine in relapsed and treatment refractory acute myeloid …
JP Bewersdorf, S Giri, R Wang, RT Williams… - …, 2020 - ncbi.nlm.nih.gov
Recent clinical data have shown a synergistic effect of venetoclax in combination with the
hypomethylating agents (HMA) azacitidine and decitabine (complete remission [CR]/CR with …
hypomethylating agents (HMA) azacitidine and decitabine (complete remission [CR]/CR with …