Radiopharmaceutical validation for clinical use
CA Kunos, R Howells, A Chauhan, ZW Myint… - Frontiers in …, 2021 - frontiersin.org
Radiopharmaceuticals are reemerging as attractive anticancer agents, but there are no
universally adopted guidelines or standardized procedures for evaluating agent validity …
universally adopted guidelines or standardized procedures for evaluating agent validity …
A high throughput screen with a clonogenic endpoint to identify radiation modulators of cancer
NP Gomes, B Frederick, JR Jacobsen… - Radiation …, 2023 - meridian.allenpress.com
Clonogenic assays evaluate the ability of single cells to proliferate and form colonies. This
process approximates the regrowth and recurrence of tumors after treatment with radiation …
process approximates the regrowth and recurrence of tumors after treatment with radiation …
Target-based radiosensitization strategies: concepts and companion animal model outlook
MR Berry, TM Fan - Frontiers in oncology, 2021 - frontiersin.org
External beam radiotherapy is indicated in approximately 50-60% of human cancer patients.
The prescribed dose of ionizing radiation that can be delivered to a tumor is determined by …
The prescribed dose of ionizing radiation that can be delivered to a tumor is determined by …
Translation of targeted radiation sensitizers into clinical trials
ZR Reichert, DR Wahl, MA Morgan - Seminars in Radiation Oncology, 2016 - Elsevier
Over the past century, technologic advances have promoted the evolution of radiation
therapy into a precise treatment modality allowing for the maximal administration of dose to …
therapy into a precise treatment modality allowing for the maximal administration of dose to …
Mechanisms and markers of clinical radioresistance
Predictive biomarkers that allow rational selection of treatments for individual patients have
played a central role in precision oncology. While such biomarkers have transformed …
played a central role in precision oncology. While such biomarkers have transformed …
Preclinical evaluation of molecular-targeted anticancer agents for radiotherapy
The combination of molecular-targeted agents with irradiation is a highly promising avenue
for cancer research and patient care. Molecular-targeted agents are in themselves not …
for cancer research and patient care. Molecular-targeted agents are in themselves not …
Advances in molecular targeted therapies to increase efficacy of (chemo) radiation therapy
K Viktorsson, T Rieckmann, M Fleischmann… - Strahlentherapie und …, 2023 - Springer
Recent advances in understanding the tumor's biology in line with a constantly growing
number of innovative technologies have prompted characterization of patients' individual …
number of innovative technologies have prompted characterization of patients' individual …
Improving the efficacy of chemoradiation with targeted agents
MA Morgan, LA Parsels, J Maybaum, TS Lawrence - Cancer discovery, 2014 - AACR
Chemoradiation is the standard therapy for the majority of inoperable, locally advanced
cancers. Although there is a need to improve chemoradiation efficacy, normal-tissue toxicity …
cancers. Although there is a need to improve chemoradiation efficacy, normal-tissue toxicity …
[HTML][HTML] Improving radiotherapy in cancer treatment: Promises and challenges
HHW Chen, MT Kuo - Oncotarget, 2017 - ncbi.nlm.nih.gov
Effective radiotherapy for cancer has relied on the promise of maximally eradicating tumor
cells while minimally killing normal cells. Technological advancement has provided state-of …
cells while minimally killing normal cells. Technological advancement has provided state-of …
Improving the efficacy of tumor radiosensitization through combined molecular targeting
K Hintelmann, M Kriegs, K Rothkamm… - Frontiers in …, 2020 - frontiersin.org
Chemoradiation, either alone or in combination with surgery or induction chemotherapy, is
the current standard of care for most locally advanced solid tumors. Though chemoradiation …
the current standard of care for most locally advanced solid tumors. Though chemoradiation …