The addition of chemotherapeutic agents to ionizing radiation has improved survival in many
malignancies. Cure rates may be further improved by adding novel targeted agents to …

The last two decades have seen technological developments that have led to more accurate
delivery of radiation therapy (RT), which has resulted in clinical gains in many solid tumors …

There is an urgent need to improve reproducibility and translatability of preclinical data to
fully exploit opportunities for molecular therapeutics involving radiation and …

Purpose The combination of cytotoxic chemotherapy with radiation therapy (CRT) has
resulted in significant improvements in clinical outcomes for patients with many locally …

Radiation therapy is a pillar of oncologic care for various solid malignancies in the curative
and palliative settings. Technologic advancements spanning over a century have now …

Radiation therapy is a highly effective cancer treatment modality, and extensive
investigations have been undertaken over the years to augment its efficacy in the clinic. This …

A number of oncology phase II radiochemotherapy trials with promising results have been
conducted late in the overall experimental therapeutic agent development process …

Traditional cytotoxic agents used in cancer therapy were initially discovered based on their
ability to kill rapidly dividing cells. The targets of these early-generation agents were typically …

Radiotherapy has been optimized over the last decades not only through technological
advances, but also through the translation of biological knowledge into clinical treatment …

Purpose: To review the many changes which have occurred in the past decades in the field
of predicting outcome after radiotherapy from biological characteristics of the tumour or …