Integrative radiogenomic profiling of squamous cell lung cancer

ME Abazeed, DJ Adams, KE Hurov, P Tamayo… - Cancer research, 2013 - AACR
Radiotherapy is one of the mainstays of anticancer treatment, but the relationship between
the radiosensitivity of cancer cells and their genomic characteristics is still not well defined …

The clinical development of molecularly targeted agents in combination with radiation therapy: a pharmaceutical perspective

OU Ataman, SJ Sambrook, C Wilks, A Lloyd… - International Journal of …, 2012 - Elsevier
This paper explores historical and current roles of pharmaceutical industry sponsorship of
clinical trials testing radiation therapy combinations with molecularly targeted agents and …

Radiogenomics predicting tumor responses to radiotherapy in lung cancer

AK Das, MH Bell, CS Nirodi, MD Story… - Seminars in radiation …, 2010 - Elsevier
The recently developed ability to interrogate genome-wide data arrays has provided
invaluable insights into the molecular pathogenesis of lung cancer. These data have also …

Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches

F Dumont, A Altmeyer, P Bischoff - Expert opinion on therapeutic …, 2009 - Taylor & Francis
Background: The efficacy of radiotherapy (RT) for cancer treatment is limited by normal
tissue toxicity and by the intrinsic or acquired radioresistance of many tumours. Therefore …

Increasing the therapeutic ratio of radiotherapy

PJ Tofilon, K Camphausen - 2017 - Springer
Cancer Drug Discovery and Development, the Springer series headed by Beverly A.
Teicher, is the definitive book series in cancer research and oncology. Volumes cover the …

[图书][B] Molecular radio-oncology

M Baumann, M Krause, N Cordes - 2016 - Springer
This textbook on Molecular Radio-Oncology is targeting physicians and preclinical
researchers with interest in translational radiation oncology. The first part of the book takes …

[PDF][PDF] Combining radiation and molecular targeting in cancer therapy

K Camphausen, PJ Tofilon - Cancer biology & therapy, 2004 - Taylor & Francis
Radiotherapy continues to remain a major treatment modality for solid tumors. However,
advances in fundamental radiobiology suggest that improvements in tumor control can be …

Translation of precision medicine research into biomarker-informed care in radiation oncology

JA Scarborough, JG Scott - Seminars in radiation oncology, 2022 - Elsevier
The reach of personalized medicine in radiation oncology has expanded greatly over the
past few decades as technical precision has improved the delivery of radiation to each …

[HTML][HTML] Model selection for the preclinical development of new drug–radiotherapy combinations

J Singh, S Hatcher, AA Ku, Z Ding, FY Feng… - Clinical Oncology, 2021 - Elsevier
Radiotherapy plays an essential role in the treatment of more than half of all patients with
cancer. In recent decades, advances in devices that deliver radiation and the development …

Moving beyond the standard of care: accelerate testing of radiation-drug combinations

SH Lin, H Willers, S Krishnan, JN Sarkaria… - International Journal of …, 2021 - Elsevier
Radiation therapy is a major treatment modality used in> 60% of cancer patients as
definitive local treatment for inoperable locoregionally confined tumors and as palliative …