Radiation is used in various cancer treatment regimens. However, hypoxia—a hallmark of
the tumor microenvironment (TME)—drives disease progression and limits response to …

The last few years have seen a significant increase in our understanding of the molecular
pathways governing cell function in cancer. This has led to an explosive interest in novel …

Radiosensitivity can be influenced both by factors intrinsic and extrinsic to the cancer cell.
One of the factors in the tumor microenvironment (TME) extrinsic to the cancer cell that can …

The practice of radiation oncology is primarily based on precise technical delivery of highly
conformal, image-guided external beam radiotherapy or brachytherapy. However …

Abstract Purpose of Review Radiogenomics is a growing field that has garnered immense
interest over the past decade, owing to its numerous applications in the field of oncology and …

Background Personalized radiation therapy holds the promise that the diagnosis,
prevention, and treatment of cancer will be based on individual assessment of risk. Although …

Ionizing radiation has been shown to activate and interact with multiple growth factor
receptor pathways that can influence tumor response to therapy. Among these receptor …

Background Despite new radiotherapeutic strategies, radioresistance in head and neck
squamous cell carcinoma (HNSCC) remains a major problem. Preclinical model systems …

Despite radiation therapy (RT) being an integral part of the treatment of most pediatric
cancers and the recent discovery of novel molecular‐targeted agents (MTAs) in this era of …

Our increased understanding of the molecular processes underlying cellular sensitivity to
ionizing radiation has led to the identification of novel targets for intervention. New agents …