The application of radiotherapy to the treatment of cancer has existed for over 100 years.
Although its use has cured many, much work remains to be done to minimize side effects …

New drugs aiming at the development of targeted therapies have been assayed in
combination with ionizing radiation over the past few years. The rationale of this concept …

In a time of rapid advances in science and technology, the opportunities for radiation
oncology are undergoing transformational change. The linkage between and understanding …

Concurrent administration of radiation and chemotherapy has emerged as a dominant form
of cancer treatment. Nevertheless, our understanding of the specific mechanisms of …

Radiation therapy is a critical component in the curative management of many solid tumor
types, and advances in radiation delivery techniques during the past decade have led to …

Abstract The work of Al Knudson created the paradigm in which we see cancer as a result of
the accumulation of multiple mutations. Our goal has been to exploit these mutations to …

Molecular biology approaches in radiobiology and radiation oncology have improved our
understanding of cellular radiation responses of both tumor and normal cells. These involve …

Recent advances in our understanding of the biology of cancer have provided enormous
opportunities for the development of novel therapies against specific molecular targets. It is …

There is a need for preclinical models that can enable identification of novel radiosensitizing
drugs in clinically relevant high-throughput experiments. We used a new high-throughput …

Throughout the decade since the National Institute of Biomedical Imaging and
Bioengineering was established, molecular imaging has continued gaining acceptance as a …