Noninvasive characterization of human glymphatics and meningeal lymphatics in an in vivo model of blood–brain barrier leakage

CH Wu, JF Lirng, YH Ling, YF Wang, HM Wu… - Annals of …, 2021 - Wiley Online Library
Objective To evaluate human glymphatics and meningeal lymphatics noninvasively.
Methods This prospective study implemented 3‐dimensional (3D) isotropic contrast …

[引用][C] Anatomical pathways for lymphatic drainage of the brain and their pathological significance

S Kida, RO Weller, ET Zhang… - Neuropathology and …, 1995 - Wiley Online Library
Drainage of cerebrospinal and interstitial fluid from the brain into deep cervical lymph nodes
has been well documented in a number of mammalian species [l]. Tracer studies have …

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

A Aspelund, S Antila, ST Proulx, TV Karlsen… - Journal of Experimental …, 2015 - rupress.org
The central nervous system (CNS) is considered an organ devoid of lymphatic vasculature.
Yet, part of the cerebrospinal fluid (CSF) drains into the cervical lymph nodes (LNs). The …

Effects of increased intracranial pressure on cerebrospinal fluid influx, cerebral vascular hemodynamic indexes, and cerebrospinal fluid lymphatic efflux

T Xiang, D Feng, X Zhang, Y Chen… - Journal of Cerebral …, 2022 - journals.sagepub.com
The glymphatic-lymphatic fluid transport system (GLFTS) consists of glymphatic pathway
and cerebrospinal fluid (CSF) lymphatic outflow routes, allowing biological liquids from the …

[HTML][HTML] Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI

IF Harrison, B Siow, AB Akilo, PG Evans, O Ismail… - Elife, 2018 - elifesciences.org
The glymphatics system describes a CSF-mediated clearance pathway for the removal of
potentially harmful molecules, such as amyloid beta, from the brain. As such, its components …

A SPECT-based method for dynamic imaging of the glymphatic system in rats

B Sigurdsson, NL Hauglund, TO Lilius… - Journal of Cerebral …, 2023 - journals.sagepub.com
The glymphatic system is a brain-wide waste drainage system that promotes cerebrospinal
fluid circulation through the brain to remove waste metabolites. Currently, the most common …

Computational modelling of fluid and solute transport in the brain

AD Martinac, LE Bilston - Biomechanics and modeling in mechanobiology, 2020 - Springer
The glymphatic system is proposed to be a unidirectional fluid and solute circulation
pathway in the brain involving transport through perivascular spaces, brain interstitium and …

Lymphatic drainage of the brain and the pathophysiology of neurological disease

RO Weller, E Djuanda, HY Yow, RO Carare - Acta neuropathologica, 2009 - Springer
There are no conventional lymphatics in the brain but physiological studies have revealed a
substantial and immunologically significant lymphatic drainage from brain to cervical lymph …

[引用][C] Physiology and immunology of lymphatic drainage of interstitial and cerebrospinal fluid from the brain

PM Knopf, HF Cserr, SC Nolan, TY Wu… - Neuropathology and …, 1995 - Wiley Online Library
Cerebrospinal fluid (CSF) and brain interstitial fluid, extracellular fluids produced in the
central nervous system (CNS). efflux by several routes (Figure 1)[reviewed in 4, 51. A major …

[PDF][PDF] The brain and the lymphatic system (I)

M Foldi - Lymphology, 1996 - journals.uair.arizona.edu
It has been generally accepted that there are no lymphatic vessels in the brain. Because
“tight junctions” characteristic of brain microvessels sharply limit the egress of plasma …