Background Evaluation of the glymphatic system with intrathecal contrast material injection
has limited clinical use. Purpose To investigate the feasibility of using serial intravenous …

Intracranial cerebrospinal and interstitial fluid (ISF) flow and solute transport have important
clinical implications, but limited in vivo access to the brain interior leaves gaping holes in …

The recently proposed glymphatic system suggests that bulk flow is important for clearing
waste from the brain, and as such may underlie the development of eg Alzheimer's disease …

The recent discovery of the meningeal lymphatic vessels (mLVs) and glymphatic pathways
has challenged the long-lasting dogma that the central nervous system (CNS) lacks a …

The glymphatic system is a recently defined brain-wide paravascular pathway for
cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange that facilitates efficient …

Although the brain lacks conventional lymphatic vessels found in peripheral tissue, evidence
suggests that the space surrounding the vasculature serves a similar role in the clearance of …

This review surveys evidence for the flow of brain interstitial fluid (ISF) via preferential
pathways through the brain, and its relation to cerebrospinal fluid (CSF). Studies over> 100 …

Background Mouse models are commonly used to study central nervous system disorders,
in which cerebrospinal fluid (CSF) drainage may be disturbed. However, mouse CSF …

Fluid transport in the perivascular space by the glia-lymphatic (glymphatic) system is
important for the removal of solutes from the brain parenchyma, including peptides such as …

The glymphatic system of cerebrospinal fluid transport through the perivascular spaces of
the brain has been implicated in metabolic waste clearance, neurodegenerative diseases …