We demonstrated previously that about one-half of cerebrospinal fluid (CSF) removed from
the cranial vault was cleared by extracranial lymphatic vessels. In this report we test the …

Purpose The diffusion tensor image analysis along the perivascular space (DTI-ALPS)
method was developed to evaluate the brain's glymphatic function or interstitial fluid …

BACKGROUND: The flow of cerebrospinal fluid (CSF) has been described as a
unidirectional system with the choroid plexus serving as the primary secretor of CSF and the …

To what extent does the subarachnoid cerebrospinal fluid (CSF) compartment communicate
directly with the extravascular compartment of human brain tissue? Interconnection between …

BACKGROUND AND PURPOSE: Hypertension may be related to alterations of the
glymphatic system, a waste metabolite drainage system in the brain. We aimed to …

The paravascular pathway, also known as the “glymphatic” pathway, is a recently described
system for waste clearance in the brain. According to this model, cerebrospinal fluid (CSF) …

Blood-borne substances can invade into the extracellular spaces of the brain via endothelial
cells in sites without the blood–brain barrier (BBB), and can travel through the interstitial fluid …

Objective Impaired glymphatic waste clearance function during brain aging leads to the
accumulation of metabolic waste and neurotoxic proteins (eg, amyloid-β, tau) which …

The plasma recovery of an intraventricularly administered protein was compared before and
after lymph diversion/ligation in the same conscious sheep to determine the relative roles of …

Assessing glymphatic function using in-vivo imaging method is of great value for
understanding its contribution to major brain diseases. In the present study, we aim to …