Molecular targeted radiosensitizers: opportunities and challenges

H Willers, I Eke - 2020 - books.google.com
Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader
with a comprehensive review of key pre-clinical research components required to identify …

Introduction to molecular targeted radiosensitizers: opportunities and challenges

H Willers, I Eke - Molecular Targeted Radiosensitizers: Opportunities …, 2020 - Springer
The practice of radiation oncology is currently primarily based on precise technical delivery
of highly conformal, image-guided radiation treatments. The precision medicine revolution …

Preclinical strategies for testing of targeted radiosensitizers

SH Lin, R Ye, Y Wang - Molecular Targeted Radiosensitizers …, 2020 - Springer
Use of radiation for cancer therapy began shortly after the discovery of X-rays in 1895.
Technological advances over the ensuing 120 years have enabled the development of …

On the path to seeking novel radiosensitizers

D Katz, E Ito, FF Liu - International Journal of Radiation Oncology* Biology …, 2009 - Elsevier
Radiation therapy is a highly effective cancer treatment modality, and extensive
investigations have been undertaken over the years to augment its efficacy in the clinic. This …

Molecular targets for tumor radiosensitization

PJ Tofilon, K Camphausen - Chemical reviews, 2009 - ACS Publications
It is estimated that in 2008 1.4 million patients in North America will be diagnosed with a
nonskin form of cancer (www. cancer. org), of which seventy-five percent will receive …

[HTML][HTML] Screening and validation of molecular targeted radiosensitizers

H Willers, X Pan, N Borgeaud, I Korovina, L Koi… - International Journal of …, 2021 - Elsevier
The development of molecular targeted drugs with radiation and chemotherapy is critically
important for improving the outcomes of patients with hard-to-treat, potentially curable …

Mechanisms and markers of clinical radioresistance

MS Binkley, M Diehn, I Eke, H Willers - … Radiosensitizers: Opportunities and …, 2020 - Springer
Predictive biomarkers that allow rational selection of treatments for individual patients have
played a central role in precision oncology. While such biomarkers have transformed …

Opportunities and challenges in the era of molecularly targeted agents and radiation therapy

SH Lin, TJ George, E Ben-Josef… - Journal of the …, 2013 - academic.oup.com
The first annual workshop for preclinical and clinical development of radiosensitizers took
place at the National Cancer Institute on August 8–9, 2012. Radiotherapy is one of the most …

Preclinical in vivo evaluation of novel radiosensitizers by local tumor control experiments

K Schneider, N Ebert, I Kurth, M Baumann - … Opportunities and Challenges, 2020 - Springer
Over the past several years, significant technological and biological progress has been
made in radiation oncology with focus on the development of new treatment schemes to …

[HTML][HTML] Molecular targets that sensitize cancer to radiation killing: From the bench to the bedside

S Sriramulu, S Thoidingjam, SL Brown… - Biomedicine & …, 2023 - Elsevier
Radiotherapy is a standard cytotoxic therapy against solid cancers. It uses ionizing radiation
to kill tumor cells through damage to DNA, either directly or indirectly. Radioresistance is …