Implementation of vancomycin therapeutic monitoring guidelines: focus on Bayesian estimation tools in neonatal and pediatric patients

J Han, J Sauberan, MT Tran… - Therapeutic Drug …, 2022 - journals.lww.com
Background: The 2020 consensus guidelines for vancomycin therapeutic monitoring
recommend using Bayesian estimation targeting the ratio of the area under the curve over …

Vancomycin audit in the paediatric population: Patterns of use and appropriateness of therapeutic drug monitoring

M Abdel Jalil, F Khaled, F Qaryouti… - Basic & Clinical …, 2023 - Wiley Online Library
Aims This study aims to investigate prescribing and therapeutic drug monitoring (TDM)
practices for vancomycin in paediatrics at the Jordan University Hospital and to determine …

External evaluation of population pharmacokinetic models for vancomycin in neonates

T Tasa, R Kalamees, J Vilo, I Lutsar, T Metsvaht - bioRxiv, 2018 - biorxiv.org
Introduction Numerous vancomycin population pharmacokinetic (PK) models of neonates
have been published. We aimed to comparatively evaluate a set of these models by …

Vancomycin therapeutic guidelines: closer examination of neonatal pharmacokinetics

S Croes, LM Stolk - Clinical infectious diseases, 2011 - academic.oup.com
TO THE E DITOR—We read with interest the recent paper of Patel et al describing the
pharmacokinetic and pharmacodynamic profile of the vancomycin regimens according to the …

Continuous-Infusion Vancomycin—Teaching an Old Dog New Tricks?

KJ Downes - Journal of the Pediatric Infectious Diseases …, 2018 - academic.oup.com
Vancomycin is one of the most common antimicrobial agents prescribed for hospitalized
children [1]. Despite decades of clinical experience, consensus guidelines on therapeutic …

Balancing vancomycin efficacy and nephrotoxicity: should we be aiming for trough or AUC/MIC?

K Patel, AS Crumby, HD Maples - Pediatric Drugs, 2015 - Springer
Sixty years later, the question that still remains is how to appropriately utilize vancomycin in
the pediatric population. The Infectious Diseases Society of America published guidelines in …

Factors impacting unbound vancomycin concentrations in neonates and young infants

A Smits, S Pauwels, M Oyaert, N Peersman… - European Journal of …, 2018 - Springer
Vancomycin pharmacokinetic (PK) and pharmacodynamic (PD) data in neonates are based
on total concentrations. However, only unbound vancomycin is pharmacologically active …

Pharmacokinetics of vancomycin in neonates of postconceptional age less than or equal to 32 weeks

M Bafalluy, LS AP - Anales Espanoles de Pediatria, 1996 - europepmc.org
The objective of the present study was to analyze the pharmacokinetic behavior of
vancomycin in neonates of postconceptional age< or= 32 weeks (n= 44). The elimination of …

Individualized empiric vancomycin dosing in neonates using a model-based approach

A Frymoyer, C Stockmann, AL Hersh… - Journal of the …, 2019 - academic.oup.com
Background Vancomycin dosing in neonates is challenging because of the large variation in
pharmacokinetics. Existing empiric dosing recommendations use table-based formats …

Vancomycin dosing and therapeutic drug monitoring practices: guidelines versus real-life

T Van Der Heggen, FM Buyle, B Claus… - International Journal of …, 2021 - Springer
Background Correct dosing and therapeutic drug monitoring (TDM) practices are essential
when aiming for optimal vancomycin treatment. Objective To assess target attainment after …