Trypanosoma brucei gambiense (Tbg), causing the sleeping sickness chronic form,
completes its developmental cycle within the tsetse fly vector Glossina palpalis gambiensis …

African trypanosomes evade humoral immunity through antigenic variation, whereby they
switch expression of the gene encoding their VSG (variant surface glycoprotein) coat …

African trypanosomes (Trypanosoma brucei) have a digenetic lifecycle that alternates
between the mammalian bloodstream and the tsetse fly vector. In the bloodstream …

Pathogens often persist during infection because of antigenic variation in which they evade
immunity by switching between distinct surface antigen variants. A central question is how …

Introduction: Trypanosoma brucei uses antigenic variation to evade the host antibody
clearance by periodically changing its Variant Surface Glycoprotein (VSGs) coat. T. brucei …

Antigenic variation is a common microbial survival strategy, powered by diversity in
expressed surface antigens across the pathogen population over the course of infection …

In Trypanosoma brucei, the active variant surface glycoprotein genes (vsg) are located at
telomeric expression sites (ES), whose expression is highly regulated during the life cycle. In …

The protozoan Trypanosoma brucei, responsible for animal and human trypanosomiasis,
has a family of major surface proteases (MSPs) and phospholipase-C (PLC), both involved …

Trypanosoma brucei switches between variant surface glycoproteins (VSGs) allowing
immune escape. The active VSG is in one of many telomeric bloodstream form VSG …

Background Trypanosoma brucei brucei, the parasite causing Nagana in domestic animals,
is closely related to the parasites causing sleeping sickness, but does not infect humans. In …