Fibrosis can occur in almost all tissues and organs and affects normal physiological function,
which may have serious consequences, such as organ failure. However, there are currently …

Background: Hypertrophic scars (HS) often occur after burns, surgery and extensive trauma.
Krüppel-like factor 4 (KLF4) is a member of the Krüppel-like factor family, a group of …

Transforming growth factor (TGF)-β1 induces fibroblast transdifferentiation to myofibroblasts,
a process that requires the involvement of integrin-mediated signaling and focal adhesion …

Fibrosis, characterized by sustained activation of myofibroblasts and excessive extracellular
matrix (ECM) deposition, is known to be associated with chronic inflammation. Receptor …

Background Initially identified as a molecule that regulates the final step of glycolysis, the M2
isoform of pyruvate kinase (PKM2) was recently reported to have a central role in the …

Hypertensive cardiac remodelling is a common cause of heart failure. However, the
molecular mechanisms regulating cardiac remodelling remain unclear. Pyruvate kinase …

Interstitial fibrosis is a typical feature of end-stage renal diseases, regardless of the initial
cause of kidney injury. Epithelial-to-mesenchymal transition (EMT) is a mechanism that is …

The factors that determine fibrosis progression or normal tissue repair are largely unknown.
We previously demonstrated that autophagy inhibition-mediated epithelial–mesenchymal …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease characterized by
extensive extracellular matrix (ECM) deposition by activated myofibroblasts, which are …

The pathways which regulate resolution of inflammation and contribute to positive
remodeling of the myocardium following injury are poorly understood. Here we show that …