Glioblastoma (GBM) is the most common and malignant type of primary brain tumor. It
represents one of the deadliest human cancers, with an average survival at diagnosis of …

Brain tumors remain one of the most difficult tumors to treat and, depending on the
diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common …

Simple Summary Glioblastomas (GBMs) are the most frequent and aggressive malignant
tumors arising in the human brain. One of the main reasons for GBM aggressiveness is its …

Glioblastoma (GBM) is the most aggressive and common form of brain cancer in adults.
GBM is characterized by poor survival and remarkably high tumors heterogeneity (both …

Glioblastoma (GBM) is one of the deadliest types of cancer and highly refractory to
chemoradiation and immunotherapy. One of the main reasons for this resistance to therapy …

Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …

Glioblastoma (GBM), the most common primary malignant brain tumor in adults, is
associated with significant morbidity and mortality despite maximal safe resection followed …

Glioblastoma (GBM) was previously classified into four subtypes (classical, neural,
proneural, and mesenchymal) based on transcriptional features; however, the original …

Gliomas are a heterogeneous group of tumors that show variable proliferative potential,
invasiveness, aggressiveness, histological grading, and clinical behavior. In this review, we …

Heterogeneity is a hallmark of tumors and has a crucial role in the outcome of the
malignancy, because it not only confounds diagnosis, but also challenges the design of …