Integrative transcriptomic and metabolomic analyses unveil tanshinone biosynthesis in Salvia miltiorrhiza root under N starvation stress

LL Lu, YX Zhang, YF Yang - Plos one, 2022 - journals.plos.org
Salvia miltiorrhiza is a model plant for Chinese herbal medicine with significant
pharmacologic effects due to its tanshinone components. Our previous study indicated that …

DNA methylation regulates biosynthesis of tanshinones and phenolic acids during growth of Salvia miltiorrhiza

X He, Y Chen, Y Xia, X Hong, H You, R Zhang… - Plant …, 2024 - academic.oup.com
DNA methylation plays a crucial role in the regulation of plant growth and the biosynthesis of
secondary metabolites. Danshen (Salvia miltiorrhiza) is a valuable Chinese herbal medicine …

The Smi-miR858a-SmMYB module regulates tanshinone and phenolic acid biosynthesis in Salvia miltiorrhiza

B Zhu, M Wang, Y Pang, X Hu, C Sun… - Horticulture …, 2024 - academic.oup.com
Tanshinones and phenolic acids are two major classes of bioactive compounds in Salvia
miltiorrhiza. Revealing the regulatory mechanism of their biosynthesis is crucial for quality …

Functional Divergence of Diterpene Syntheses in the Medicinal Plant Salvia miltiorrhiza

G Cui, L Duan, B Jin, J Qian, Z Xue, G Shen… - Plant …, 2015 - academic.oup.com
The medicinal plant Salvia miltiorrhiza produces various tanshinone diterpenoids that have
pharmacological activities such as vasorelaxation against ischemia reperfusion injury and …

SmKSL overexpression combined with elicitor treatment enhances tanshinone production from Salvia miltiorrhiza hairy roots

T Wei, K Deng, Y Gao, L Chen, W Song… - Biochemical …, 2020 - Elsevier
Tanshinones are compounds of diterpenoid, which are used in the treatment of
cardiovascular diseases; however there is an urgent need to improve their production using …

Enhancing diterpenoid concentration in Salvia miltiorrhiza hairy roots through pathway engineering with maize C1 transcription factor

S Zhao, J Zhang, R Tan, L Yang… - Journal of Experimental …, 2015 - academic.oup.com
Tanshinones are valuable natural diterpenoids from danshen (Salvia miltiorrhiza Bunge).
Here, it was demonstrated that maize transcription factor C1 improved the accumulation of …

Genome-wide characterisation and analysis of bHLH transcription factors related to tanshinone biosynthesis in Salvia miltiorrhiza

X Zhang, H Luo, Z Xu, Y Zhu, A Ji, J Song, S Chen - Scientific reports, 2015 - nature.com
Abstract Salvia miltiorrhiza Bunge (Labiatae) is an emerging model plant for traditional
medicine and tanshinones are among the pharmacologically active constituents of this plant …

Expression patterns of some genes involved in tanshinone biosynthesis in Salvia miltiorrhiza roots

Y Yang, S Hou, W Fan, L Lilan, N Hui, W Xia… - Industrial Crops and …, 2019 - Elsevier
Tanshinones are the major bioactive components of Salvia miltiorrhiza, and synthesized
through the cytosol-localized mevalonic acid (MVA) and plastid-localized methylerythritol 4 …

SmGRAS3 negatively responds to GA signaling while promotes tanshinones biosynthesis in Salvia miltiorrhiza

W Li, B Xing, R Mao, Z Bai, D Yang, J Xu… - Industrial crops and …, 2020 - Elsevier
Salvia miltiorrhiza Bunge is the origin plant of traditional Chinese medicine, Danshen.
Demand of high-quality S. miltiorrhiza is increasing because of its excellent pharmaceutical …

[HTML][HTML] SmbHLH60 and SmMYC2 antagonistically regulate phenolic acids and anthocyanins biosynthesis in Salvia miltiorrhiza

S Liu, Y Wang, M Shi, I Maoz, X Gao, M Sun… - Journal of Advanced …, 2022 - Elsevier
Introduction Salvia miltiorrhiza is a renowned traditional Chinese medicinal plant with
extremely high medicinal value, especially for cardiovascular and cerebrovascular diseases …