Natural gossypol (GP), a polyphenolic pigment in cottonseed, is a racemic mixture of two
enantiomers,(+) GP and (-) GP. Our aim was to compare the abilities of (+/-) GP,(+) GP and …

Abstract Gossypol [(2, 2′-binaphthalene)-8, 8′-dicarboxaldehyde-1, 1′, 6, 6′, 7, 7′-
hexahydroxy-5, 5′-diisopropyl-3, 3′-dimethyl] 1a is a naturally occurring compound …

The naturally occurring compound, gossypol, has been previously used as a male oral
contraceptive, for the treatment of benign gynaecological conditions and cancer patients …

Estrogen stimulates the growth of hormone-dependent human breast cancer. Failure of
chemotherapy frequently results from the development of multidrug resistance. Gossypol …

Several cell lines resistant to alkylating agents possess increased activity of gluthathione-S-
transferase (GST) drug detoxifying enzymes. Inhibition of certain enzymes of the …

Gossypol, a polyphenolic, aldehyde-containing constituent of cottonseed, produced partial
responses (> 50% reduction in tumor size) in some patients with advanced cancer and …

Gossypol has demonstrated in vitro effects on cell cycle regulation and anti-tumor activity
against mammary carcinoma cell lines. This Phase I/II study assesses both the effect of …

The antiproliferative effect of gossypol and its optical isomers on various human cell lines of
reproductive and nonreproductive tissue origin was studied. Various reproductive cancer …

Abstract The cytotoxicity of the (-)-and (+)-isomers and the quinone metabolite gossypolone
prepared from the naturally occurring polyphenolic dialdehyde gossypol were compared …

Gossypol, a phenolic compound extracted from the cotton plant, has been used as an oral
male contraceptive in China; few side effects other than transient hypokalaemia have been …