Abstract The Guardian of the Genome p53 has been established as a potent tumour
suppressor. However, culminating from seminal findings in rodents more than a decade ago …

Mitochondrial dysfunction is closely associated with reactive oxygen species (ROS)
generation and oxidative stress in cells. On the other hand, modulation of the cellular …

The present study was conducted to determine the effects of acute overload exercise on
mitochondrial DNA and the structure of skeletal muscles. Rats were forced to run for 20 min …

Background Elderly populations are susceptible to critical limb ischemia (CLI), but
conventional treatments cannot significantly decrease amputation and mortality. Although …

Background and Aim: Myocardial infarction (MI) is accompanied by increased reactive
oxygen species (ROS) which causes DNA damage and mitochondria dysfunction, resulting …

Aim Endurance exercise (EE) has been reported to confer neuroprotection against
Parkinson's disease (PD); however, underlying molecular mechanisms of the protection …

Background Mitochondrial dynamics disorders contribute to the pathogenesis of many
diseases involving type 2 diabetes. It appears that exercise training is a strategy for …

Background Recent studies showed a link between a high fat diet (HFD)-induced obesity
and lipid accumulation in non-adipose tissues, such as skeletal muscle and liver, and insulin …

Chronic contractile activity produces mitochondrial biogenesis in muscle. This adaptation
results in a significant shift in adenine nucleotide metabolism, with attendant improvements …