Rho family GTPases act as transducers of signals from extracellular stimuli to the
cytoskeleton and gene expression. Their actions are temporal and spatial determinants for …

RhoB is a mainly endosomal small GTPase that regulates actin organization and vesicle
trafficking. Expression of RhoB is elevated rapidly by many stimuli, including growth factors …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

The Rho subfamily members of Rho GTPases, RhoA, RhoB, and RhoC, are key regulators
of signal transduction in a variety of cellular processes, including regulation of actomyosin …

The Ras-related guanosine triphosphatase RhoA mediates pathological cardiac
hypertrophy, but also promotes cell survival and is cardioprotective after …

Rho-class small GTPases are implicated in basic cellular processes at nearly all brain
developmental steps, from neurogenesis and migration to axon guidance and synaptic …

Signaling through the Rho family of small GTPases has been increasingly investigated for
their involvement in a wide variety of diseases such as cardiovascular, pulmonary, and …

A variety of neurons generated during embryonic development survive or undergo
programmed cell death (PCD) at later developmental stages. Survival or death of …

Rac1, a member of the Rho family of GTPases, is an intracellular transducer known to
regulate multiple signaling pathways that control cytoskeleton organization, transcription …

Rho GTPases regulate many important processes in all eukaryotic cells, including the
organization of the actin cytoskeleton, gene transcription, cell cycle progression, and …